PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 37,481 Value ($000) $11,047 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 19,796 Value ($000) $1,049 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 19,056 Value ($000) $801 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 12,208 Value ($000) $462 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 47,993 Value ($000) $3,694 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 46,364 Value ($000) $2,668 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 21,077 Value ($000) $872 Avg Close $47.26 Range $33.01 - $63.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	37,481	$11,047	$186.22	$50.31 - $317.72
Q3 2025	19,796	$1,049	$48.49	$37.19 - $61.03
Q2 2025	19,056	$801	$38.08	$26.70 - $46.93
Q1 2025	12,208	$462	$62.45	$30.01 - $91.83
Q4 2024	47,993	$3,694	$72.36	$55.33 - $86.93
Q3 2024	46,364	$2,668	$54.02	$38.99 - $63.93
Q2 2024	21,077	$872	$47.26	$33.01 - $63.00