PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

DEERFIELD MANAGEMENT COMPANY, L.P.'s Holding History (CIK: 0001009258)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 903,351 Value ($000) $266,254 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 840,851 Value ($000) $44,565 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 686,931 Value ($000) $28,885 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 619,931 Value ($000) $23,477 Avg Close $62.45 Range $30.01 - $91.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	903,351	$266,254	$186.22	$50.31 - $317.72
Q3 2025	840,851	$44,565	$48.49	$37.19 - $61.03
Q2 2025	686,931	$28,885	$38.08	$26.70 - $46.93
Q1 2025	619,931	$23,477	$62.45	$30.01 - $91.83