PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 23,098 Value ($000) $6,808 Avg Close $186.22 Range $50.31 - $317.72
Q3 2025
Shares 5,508 Value ($000) $292 Avg Close $48.49 Range $37.19 - $61.03
Q2 2025
Shares 6,509 Value ($000) $274 Avg Close $38.08 Range $26.70 - $46.93
Q1 2025
Shares 18,808 Value ($000) $712 Avg Close $62.45 Range $30.01 - $91.83
Q4 2024
Shares 20,066 Value ($000) $1,544 Avg Close $72.36 Range $55.33 - $86.93
Q3 2024
Shares 22,766 Value ($000) $1,310 Avg Close $54.02 Range $38.99 - $63.93
Q2 2024
Shares 23,966 Value ($000) $991 Avg Close $47.26 Range $33.01 - $63.00
Q1 2024
Shares 23,372 Value ($000) $1,426 Avg Close $44.86 Range $20.50 - $67.21
Q4 2023
Shares 9,426 Value ($000) $210 Avg Close $18.01 Range $13.01 - $27.60