PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 69,242 Value ($000) $20,408 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 68,141 Value ($000) $3,611 Avg Close $48.49 Range $37.19 - $61.03

Q4 2024

Shares 58,305 Value ($000) $4,487 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 170,095 Value ($000) $9,787 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 248,381 Value ($000) $10,273 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 121,024 Value ($000) $7,385 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 48,842 Value ($000) $1,088 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	69,242	$20,408	$186.22	$50.31 - $317.72
Q3 2025	68,141	$3,611	$48.49	$37.19 - $61.03
Q4 2024	58,305	$4,487	$72.36	$55.33 - $86.93
Q3 2024	170,095	$9,787	$54.02	$38.99 - $63.93
Q2 2024	248,381	$10,273	$47.26	$33.01 - $63.00
Q1 2024	121,024	$7,385	$44.86	$20.50 - $67.21
Q4 2023	48,842	$1,088	$18.01	$13.01 - $27.60