PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 373,787 Value ($000) $110,170 Avg Close $186.22 Range $50.31 - $317.72

Q4 2024

Shares 761,955 Value ($000) $58,640 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 761,955 Value ($000) $43,843 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 1,235,599 Value ($000) $51,104 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 828,380 Value ($000) $50,548 Avg Close $44.86 Range $20.50 - $67.21

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	373,787	$110,170	$186.22	$50.31 - $317.72
Q4 2024	761,955	$58,640	$72.36	$55.33 - $86.93
Q3 2024	761,955	$43,843	$54.02	$38.99 - $63.93
Q2 2024	1,235,599	$51,104	$47.26	$33.01 - $63.00
Q1 2024	828,380	$50,548	$44.86	$20.50 - $67.21