PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Zurcher Kantonalbank (Zurich Cantonalbank)'s Holding History (CIK: 0001368163)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 98 Value ($000) $29 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 98 Value ($000) $5 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 167 Value ($000) $7 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 167 Value ($000) $6 Avg Close $62.45 Range $30.01 - $91.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	98	$29	$186.22	$50.31 - $317.72
Q3 2025	98	$5	$48.49	$37.19 - $61.03
Q2 2025	167	$7	$38.08	$26.70 - $46.93
Q1 2025	167	$6	$62.45	$30.01 - $91.83