PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Bank of New York Mellon Corp's Holding History (CIK: 0001390777)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 77,897 Value ($000) $22,959 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 56,288 Value ($000) $2,983 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 52,553 Value ($000) $2,210 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 46,307 Value ($000) $1,754 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 46,856 Value ($000) $3,606 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 48,207 Value ($000) $2,774 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 49,510 Value ($000) $2,048 Avg Close $47.26 Range $33.01 - $63.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	77,897	$22,959	$186.22	$50.31 - $317.72
Q3 2025	56,288	$2,983	$48.49	$37.19 - $61.03
Q2 2025	52,553	$2,210	$38.08	$26.70 - $46.93
Q1 2025	46,307	$1,754	$62.45	$30.01 - $91.83
Q4 2024	46,856	$3,606	$72.36	$55.33 - $86.93
Q3 2024	48,207	$2,774	$54.02	$38.99 - $63.93
Q2 2024	49,510	$2,048	$47.26	$33.01 - $63.00