PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Alyeska Investment Group, L.P.'s Holding History (CIK: 0001453072)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 74,376 Value ($000) $21,922 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 141,516 Value ($000) $7,500 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 125,000 Value ($000) $5,256 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 150,000 Value ($000) $5,681 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 226,788 Value ($000) $17,454 Avg Close $72.36 Range $55.33 - $86.93

Q1 2024

Shares 25,000 Value ($000) $1,526 Avg Close $44.86 Range $20.50 - $67.21

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	74,376	$21,922	$186.22	$50.31 - $317.72
Q3 2025	141,516	$7,500	$48.49	$37.19 - $61.03
Q2 2025	125,000	$5,256	$38.08	$26.70 - $46.93
Q1 2025	150,000	$5,681	$62.45	$30.01 - $91.83
Q4 2024	226,788	$17,454	$72.36	$55.33 - $86.93
Q1 2024	25,000	$1,526	$44.86	$20.50 - $67.21