PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Connor, Clark & Lunn Investment Management Ltd.'s Holding History (CIK: 0001596800)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,870 Value ($000) $2,025 Avg Close $186.22 Range $50.31 - $317.72

Q1 2024

Shares 5,627 Value ($000) $343 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 11,531 Value ($000) $257 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,870	$2,025	$186.22	$50.31 - $317.72
Q1 2024	5,627	$343	$44.86	$20.50 - $67.21
Q4 2023	11,531	$257	$18.01	$13.01 - $27.60