PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Sofinnova Investments, Inc.'s Holding History (CIK: 0001631134)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 125,722 Value ($000) $37,055 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 172,833 Value ($000) $9,160 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 15,717 Value ($000) $661 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 157,640 Value ($000) $5,970 Avg Close $62.45 Range $30.01 - $91.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	125,722	$37,055	$186.22	$50.31 - $317.72
Q3 2025	172,833	$9,160	$48.49	$37.19 - $61.03
Q2 2025	15,717	$661	$38.08	$26.70 - $46.93
Q1 2025	157,640	$5,970	$62.45	$30.01 - $91.83