PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Qube Research & Technologies Ltd's Holding History (CIK: 0001729829)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 168,897 Value ($000) $49,781 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 57,304 Value ($000) $3,037 Avg Close $48.49 Range $37.19 - $61.03

Q4 2024

Shares 31,999 Value ($000) $2,463 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 44,703 Value ($000) $2,572 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 90,693 Value ($000) $3,751 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 132,942 Value ($000) $8,112 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 25,104 Value ($000) $559 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	168,897	$49,781	$186.22	$50.31 - $317.72
Q3 2025	57,304	$3,037	$48.49	$37.19 - $61.03
Q4 2024	31,999	$2,463	$72.36	$55.33 - $86.93
Q3 2024	44,703	$2,572	$54.02	$38.99 - $63.93
Q2 2024	90,693	$3,751	$47.26	$33.01 - $63.00
Q1 2024	132,942	$8,112	$44.86	$20.50 - $67.21
Q4 2023	25,104	$559	$18.01	$13.01 - $27.60