PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Pictet Asset Management Holding SA's Holding History (CIK: 0001993888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 240,588 Value ($000) $71,085 Avg Close $186.22 Range $50.31 - $317.72

Q2 2025

Shares 79,143 Value ($000) $3,328 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 78,588 Value ($000) $2,976 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 45,427 Value ($000) $3,496 Avg Close $72.36 Range $55.33 - $86.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	240,588	$71,085	$186.22	$50.31 - $317.72
Q2 2025	79,143	$3,328	$38.08	$26.70 - $46.93
Q1 2025	78,588	$2,976	$62.45	$30.01 - $91.83
Q4 2024	45,427	$3,496	$72.36	$55.33 - $86.93