PROTALIX BIOTHERAPEUTICS INC

Ticker: PLX CUSIP: 74365A309 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,478,176 Value ($000) $4,461 Avg Close $2.04 Range $1.60 - $2.66

Q3 2025

Shares 2,580,556 Value ($000) $5,729 Avg Close $1.63 Range $1.36 - $2.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,478,176	$4,461	$2.04	$1.60 - $2.66
Q3 2025	2,580,556	$5,729	$1.63	$1.36 - $2.26