PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

STATE OF WISCONSIN INVESTMENT BOARD's Holding History (CIK: 0000854157)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 34,786 Value ($000) $3,038 Avg Close $81.85 Range $62.24 - $96.54

Q3 2025

Shares 40,906 Value ($000) $2,717 Avg Close $56.84 Range $49.38 - $68.26

Q2 2025

Shares 32,988 Value ($000) $1,823 Avg Close $47.99 Range $39.60 - $57.70

Q1 2025

Shares 53,740 Value ($000) $2,599 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 50,782 Value ($000) $1,960 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 47,160 Value ($000) $2,122 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 55,951 Value ($000) $1,939 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 41,486 Value ($000) $1,200 Avg Close $27.21 Range $21.43 - $33.34

Q4 2023

Shares 39,799 Value ($000) $913 Avg Close $17.50 Range $13.72 - $23.88

Q3 2023

Shares 61,481 Value ($000) $1,026 Avg Close $19.40 Range $16.33 - $26.81

Q2 2023

Shares 49,677 Value ($000) $1,372 Avg Close $25.03 Range $17.64 - $30.10

Q1 2023

Shares 36,169 Value ($000) $832 Avg Close $16.79 Range $10.62 - $25.69

Q4 2022

Shares 112,195 Value ($000) $1,224 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 42,513 Value ($000) $358 Avg Close $9.46 Range $7.68 - $11.97

Q2 2022

Shares 44,333 Value ($000) $351 Avg Close $12.09 Range $6.91 - $25.76

Q1 2022

Shares 53,500 Value ($000) $1,267 Avg Close $28.17 Range $22.56 - $37.05

Q4 2021

Shares 64,600 Value ($000) $2,209 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 71,200 Value ($000) $1,262 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 61,600 Value ($000) $2,765 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 53,700 Value ($000) $1,391 Avg Close $25.31 Range $18.82 - $32.10

Q4 2020

Shares 55,400 Value ($000) $1,117 Avg Close $21.52 Range $17.44 - $25.65

Q3 2020

Shares 52,900 Value ($000) $1,034 Avg Close $18.76 Range $14.16 - $23.25

Q4 2019

Shares 22,800 Value ($000) $161 Avg Close $9.93 Range $4.47 - $13.77

Q3 2019

Shares 22,800 Value ($000) $274 Avg Close $12.60 Range $8.26 - $16.67

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	34,786	$3,038	$81.85	$62.24 - $96.54
Q3 2025	40,906	$2,717	$56.84	$49.38 - $68.26
Q2 2025	32,988	$1,823	$47.99	$39.60 - $57.70
Q1 2025	53,740	$2,599	$41.90	$33.70 - $60.60
Q4 2024	50,782	$1,960	$43.60	$33.31 - $48.89
Q3 2024	47,160	$2,122	$40.40	$32.50 - $48.00
Q2 2024	55,951	$1,939	$29.29	$24.22 - $35.96
Q1 2024	41,486	$1,200	$27.21	$21.43 - $33.34
Q4 2023	39,799	$913	$17.50	$13.72 - $23.88
Q3 2023	61,481	$1,026	$19.40	$16.33 - $26.81
Q2 2023	49,677	$1,372	$25.03	$17.64 - $30.10
Q1 2023	36,169	$832	$16.79	$10.62 - $25.69
Q4 2022	112,195	$1,224	$8.44	$7.24 - $11.46
Q3 2022	42,513	$358	$9.46	$7.68 - $11.97
Q2 2022	44,333	$351	$12.09	$6.91 - $25.76
Q1 2022	53,500	$1,267	$28.17	$22.56 - $37.05
Q4 2021	64,600	$2,209	$31.61	$17.26 - $38.11
Q3 2021	71,200	$1,262	$42.63	$12.80 - $50.54
Q2 2021	61,600	$2,765	$33.01	$24.14 - $45.93
Q1 2021	53,700	$1,391	$25.31	$18.82 - $32.10
Q4 2020	55,400	$1,117	$21.52	$17.44 - $25.65
Q3 2020	52,900	$1,034	$18.76	$14.16 - $23.25
Q4 2019	22,800	$161	$9.93	$4.47 - $13.77
Q3 2019	22,800	$274	$12.60	$8.26 - $16.67