| BlackRock, Inc. | 9,715,999 | $848,595 |
| FARALLON CAPITAL MANAGEMENT LLC | 6,144,006 | $536,617 |
| VANGUARD GROUP INC | 5,413,690 | $472,832 |
| RTW INVESTMENTS, LP | 5,059,053 | $441,858 |
| STATE STREET CORP | 3,199,729 | $279,464 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,171,423 | $276,992 |
| UBS Group AG | 2,770,021 | $241,934 |
| JANUS HENDERSON GROUP PLC | 2,649,981 | $231,355 |
| JOHNSON & JOHNSON | 2,449,183 | $213,912 |
| Invesco Ltd. | 1,567,840 | $136,935 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,452,928 | $126,920 |
| Woodline Partners LP | 1,408,772 | $123,042 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,400,738 | $122 |
| PERCEPTIVE ADVISORS LLC | 1,350,425 | $117,946 |
| CITADEL ADVISORS LLC | 1,126,687 | $98,405 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,099,170 | $96,002 |
| ADAR1 Capital Management, LLC | 1,049,168 | $91,634 |
| MARSHALL WACE, LLP | 1,024,925 | $89,517 |
| GOLDMAN SACHS GROUP INC | 961,149 | $83,947 |
| MORGAN STANLEY | 879,024 | $76,774 |
| BANK OF AMERICA CORP /DE/ | 867,580 | $75,774 |
| NORTHERN TRUST CORP | 575,118 | $50,231 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 571,825 | $49,943 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 556,762 | $48,628 |
| FMR LLC | 539,878 | $47,153 |
| AMERICAN CENTURY COMPANIES INC | 535,423 | $46,764 |
| Pictet Asset Management Holding SA | 529,631 | $46,258 |
| Clearbridge Investments, LLC | 489,842 | $42,783 |
| Commodore Capital LP | 450,000 | $39,303 |
| DIMENSIONAL FUND ADVISORS LP | 414,415 | $36,195 |
| 683 Capital Management, LLC | 380,669 | $33,248 |
| Voya Investment Management LLC | 366,165 | $31,981 |
| Bank of New York Mellon Corp | 350,388 | $30,603 |
| PRINCIPAL FINANCIAL GROUP INC | 347,932 | $30,388 |
| JENNISON ASSOCIATES LLC | 331,164 | $28,924 |
| BNP Paribas Investment Partners S.A. | 330,804 | $29 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 232,836 | $20,336 |
| NEXTBio Capital Management LP | 229,619 | $20,055 |
| KENNEDY CAPITAL MANAGEMENT LLC | 221,444 | $19,341 |
| Holocene Advisors, LP | 210,019 | $18,343 |
| Skandinaviska Enskilda Banken AB (publ) | 205,574 | $17,955 |
| Public Sector Pension Investment Board | 203,426 | $17,767 |
| Alyeska Investment Group, L.P. | 199,523 | $17,426 |
| MPM BioImpact LLC | 199,471 | $17,422 |
| AIHC Capital Management Ltd | 189,823 | $16,579 |
| BARCLAYS PLC | 187,642 | $16,389 |
| RAYMOND JAMES FINANCIAL INC | 181,503 | $15,839 |
| NAN FUNG TRINITY (HK) LTD | 180,670 | $15,780 |
| Affinity Asset Advisors, LLC | 172,125 | $15,033 |
| Boxer Capital Management, LLC | 170,000 | $14,848 |
| AMERIPRISE FINANCIAL INC | 169,518 | $14,806 |
| Duquesne Family Office LLC | 159,700 | $14 |
| TD Asset Management Inc | 158,730 | $13,863 |
| JPMORGAN CHASE & CO | 155,300 | $13,564 |
| RHUMBLINE ADVISERS | 154,950 | $13,533 |
| Qube Research & Technologies Ltd | 153,876 | $13,440 |
| Legal & General Group Plc | 149,164 | $13,028 |
| SEGALL BRYANT & HAMILL, LLC | 129,060 | $11,272 |
| Nuveen, LLC | 125,861 | $10,993 |
| PANAGORA ASSET MANAGEMENT INC | 125,384 | $10,951 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 114,036 | $9,960 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 113,340 | $9,892 |
| PRUDENTIAL FINANCIAL INC | 110,360 | $9,639 |
| Hudson Bay Capital Management LP | 109,615 | $9,574 |
| DEUTSCHE BANK AG\ | 105,460 | $9,211 |
| Opaleye Management Inc. | 105,000 | $9,171 |
| UBS ASSET MANAGEMENT AMERICAS INC | 104,528 | $9,129 |
| SOROS FUND MANAGEMENT LLC | 100,000 | $8,734 |
| NEUBERGER BERMAN GROUP LLC | 98,473 | $8,601 |
| Swiss National Bank | 98,200 | $8,577 |
| BNP PARIBAS ARBITRAGE, SA | 97,764 | $8,539 |
| CITIGROUP INC | 94,909 | $8,289 |
| AXIOM INVESTORS LLC /DE | 89,468 | $7,814 |
| Atika Capital Management LLC | 86,000 | $7,511 |
| Moody Aldrich Partners LLC | 80,623 | $7,042 |
| VICTORY CAPITAL MANAGEMENT INC | 80,571 | $7,037 |
| EAM Investors, LLC | 78,498 | $6,856 |
| FRANKLIN RESOURCES INC | 76,442 | $6,676 |
| GREAT LAKES ADVISORS, LLC | 73,966 | $6,460 |
| HighVista Strategies LLC | 73,545 | $6,423 |
| ALLIANCEBERNSTEIN L.P. | 73,222 | $6,395 |
| Knott David M Jr | 73,000 | $6,376 |
| EFG International AG | 72,623 | $6,338 |
| WELLS FARGO & COMPANY/MN | 71,645 | $6,257 |
| Fisher Asset Management, LLC | 65,114 | $5,687 |
| Rafferty Asset Management, LLC | 63,661 | $5,560 |
| STEMPOINT CAPITAL LP | 59,430 | $5,191 |
| Eagle Health Investments LP | 57,300 | $5,005 |
| Quinn Opportunity Partners LLC | 55,259 | $4,826 |
| Birchview Capital, LP | 55,000 | $4,804 |
| BESSEMER GROUP INC | 54,162 | $5 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 53,217 | $4,648 |
| KVP Capital Advisors, LP | 53,000 | $4,629 |
| Eversept Partners, LP | 52,961 | $4,626 |
| Pentwater Capital Management LP | 50,000 | $4,367 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 49,640 | $4 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 49,350 | $4 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 48,894 | $4,270 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,033 | $4,195 |
| FIRST TRUST ADVISORS LP | 46,454 | $4,057 |
| 212 other institutions | 1,885,551 | $145,055 |