PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025

Shares 47,361 Value ($000) $2,290 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 5,704 Value ($000) $220 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 26,825 Value ($000) $1,207 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 13,152 Value ($000) $456 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 35,640 Value ($000) $1,031 Avg Close $27.21 Range $21.43 - $33.34

Q2 2023

Shares 72,686 Value ($000) $2,008 Avg Close $25.03 Range $17.64 - $30.10

Q1 2023

Shares 199,516 Value ($000) $4,589 Avg Close $16.79 Range $10.62 - $25.69

Q4 2022

Shares 188,036 Value ($000) $2,051 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 143,075 Value ($000) $1,206 Avg Close $9.46 Range $7.68 - $11.97

Q4 2021

Shares 43,286 Value ($000) $1,480 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 115,913 Value ($000) $2,054 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 248,235 Value ($000) $11,141 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 200,980 Value ($000) $5,205 Avg Close $25.31 Range $18.82 - $32.10

Q4 2020

Shares 336,856 Value ($000) $6,791 Avg Close $21.52 Range $17.44 - $25.65

Q3 2020

Shares 527,833 Value ($000) $10,320 Avg Close $18.76 Range $14.16 - $23.25

Q2 2020

Shares 812,946 Value ($000) $14,356 Avg Close $12.55 Range $6.00 - $19.67

Q1 2020

Shares 280,534 Value ($000) $1,981 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 430,517 Value ($000) $3,035 Avg Close $9.93 Range $4.47 - $13.77

Q3 2019

Shares 330,169 Value ($000) $3,966 Avg Close $12.60 Range $8.26 - $16.67

Q2 2019

Shares 397,278 Value ($000) $4,811 Avg Close $11.06 Range $8.88 - $13.14

Q1 2019

Shares 257,728 Value ($000) $3,239 Avg Close $8.83 Range $6.38 - $14.36

Q4 2018

Shares 19,645 Value ($000) $132 Avg Close $7.93 Range $5.49 - $10.50

Q3 2018

Shares 11,195 Value ($000) $115 Avg Close $8.61 Range $6.57 - $11.90

Q2 2018

Shares 50,261 Value ($000) $337 Avg Close $7.68 Range $5.50 - $9.44

Q4 2017

Shares 31,251 Value ($000) $650 Avg Close $17.74 Range $14.10 - $21.31

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2025	47,361	$2,290	$41.90	$33.70 - $60.60
Q4 2024	5,704	$220	$43.60	$33.31 - $48.89
Q3 2024	26,825	$1,207	$40.40	$32.50 - $48.00
Q2 2024	13,152	$456	$29.29	$24.22 - $35.96
Q1 2024	35,640	$1,031	$27.21	$21.43 - $33.34
Q2 2023	72,686	$2,008	$25.03	$17.64 - $30.10
Q1 2023	199,516	$4,589	$16.79	$10.62 - $25.69
Q4 2022	188,036	$2,051	$8.44	$7.24 - $11.46
Q3 2022	143,075	$1,206	$9.46	$7.68 - $11.97
Q4 2021	43,286	$1,480	$31.61	$17.26 - $38.11
Q3 2021	115,913	$2,054	$42.63	$12.80 - $50.54
Q2 2021	248,235	$11,141	$33.01	$24.14 - $45.93
Q1 2021	200,980	$5,205	$25.31	$18.82 - $32.10
Q4 2020	336,856	$6,791	$21.52	$17.44 - $25.65
Q3 2020	527,833	$10,320	$18.76	$14.16 - $23.25
Q2 2020	812,946	$14,356	$12.55	$6.00 - $19.67
Q1 2020	280,534	$1,981	$7.49	$5.30 - $9.30
Q4 2019	430,517	$3,035	$9.93	$4.47 - $13.77
Q3 2019	330,169	$3,966	$12.60	$8.26 - $16.67
Q2 2019	397,278	$4,811	$11.06	$8.88 - $13.14
Q1 2019	257,728	$3,239	$8.83	$6.38 - $14.36
Q4 2018	19,645	$132	$7.93	$5.49 - $10.50
Q3 2018	11,195	$115	$8.61	$6.57 - $11.90
Q2 2018	50,261	$337	$7.68	$5.50 - $9.44
Q4 2017	31,251	$650	$17.74	$14.10 - $21.31