PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025

Shares 5,741 Value ($000) $278 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 5,658 Value ($000) $218 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 5,711 Value ($000) $257 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 82,637 Value ($000) $2,863 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 157,594 Value ($000) $4,559 Avg Close $27.21 Range $21.43 - $33.34

Q4 2023

Shares 158,843 Value ($000) $3,642 Avg Close $17.50 Range $13.72 - $23.88

Q3 2023

Shares 336,308 Value ($000) $5,610 Avg Close $19.40 Range $16.33 - $26.81

Q2 2023

Shares 376,473 Value ($000) $10,398 Avg Close $25.03 Range $17.64 - $30.10

Q1 2023

Shares 307,700 Value ($000) $7,077 Avg Close $16.79 Range $10.62 - $25.69

Q4 2022

Shares 491,965 Value ($000) $5,367 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 245,705 Value ($000) $2,071 Avg Close $9.46 Range $7.68 - $11.97

Q2 2022

Shares 315,644 Value ($000) $2,497 Avg Close $12.09 Range $6.91 - $25.76

Q1 2022

Shares 288,518 Value ($000) $6,832 Avg Close $28.17 Range $22.56 - $37.05

Q4 2021

Shares 28,100 Value ($000) $961 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 24,600 Value ($000) $436 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 73,377 Value ($000) $3,293 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 83,516 Value ($000) $2,163 Avg Close $25.31 Range $18.82 - $32.10

Q4 2020

Shares 156,366 Value ($000) $3,152 Avg Close $21.52 Range $17.44 - $25.65

Q3 2020

Shares 220,203 Value ($000) $4,305 Avg Close $18.76 Range $14.16 - $23.25

Q2 2020

Shares 289,978 Value ($000) $5,121 Avg Close $12.55 Range $6.00 - $19.67

Q1 2020

Shares 109,623 Value ($000) $774 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 203,884 Value ($000) $1,437 Avg Close $9.93 Range $4.47 - $13.77

Q3 2019

Shares 49,421 Value ($000) $594 Avg Close $12.60 Range $8.26 - $16.67

Q2 2019

Shares 122,124 Value ($000) $1,479 Avg Close $11.06 Range $8.88 - $13.14

Q1 2019

Shares 45,877 Value ($000) $577 Avg Close $8.83 Range $6.38 - $14.36

Q4 2018

Shares 57,178 Value ($000) $385 Avg Close $7.93 Range $5.49 - $10.50

Q3 2018

Shares 144,519 Value ($000) $1,487 Avg Close $8.61 Range $6.57 - $11.90

Q1 2018

Shares 32,800 Value ($000) $282 Avg Close $18.83 Range $7.85 - $23.97

Q4 2017

Shares 57,776 Value ($000) $1,202 Avg Close $17.74 Range $14.10 - $21.31

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2025	5,741	$278	$41.90	$33.70 - $60.60
Q4 2024	5,658	$218	$43.60	$33.31 - $48.89
Q3 2024	5,711	$257	$40.40	$32.50 - $48.00
Q2 2024	82,637	$2,863	$29.29	$24.22 - $35.96
Q1 2024	157,594	$4,559	$27.21	$21.43 - $33.34
Q4 2023	158,843	$3,642	$17.50	$13.72 - $23.88
Q3 2023	336,308	$5,610	$19.40	$16.33 - $26.81
Q2 2023	376,473	$10,398	$25.03	$17.64 - $30.10
Q1 2023	307,700	$7,077	$16.79	$10.62 - $25.69
Q4 2022	491,965	$5,367	$8.44	$7.24 - $11.46
Q3 2022	245,705	$2,071	$9.46	$7.68 - $11.97
Q2 2022	315,644	$2,497	$12.09	$6.91 - $25.76
Q1 2022	288,518	$6,832	$28.17	$22.56 - $37.05
Q4 2021	28,100	$961	$31.61	$17.26 - $38.11
Q3 2021	24,600	$436	$42.63	$12.80 - $50.54
Q2 2021	73,377	$3,293	$33.01	$24.14 - $45.93
Q1 2021	83,516	$2,163	$25.31	$18.82 - $32.10
Q4 2020	156,366	$3,152	$21.52	$17.44 - $25.65
Q3 2020	220,203	$4,305	$18.76	$14.16 - $23.25
Q2 2020	289,978	$5,121	$12.55	$6.00 - $19.67
Q1 2020	109,623	$774	$7.49	$5.30 - $9.30
Q4 2019	203,884	$1,437	$9.93	$4.47 - $13.77
Q3 2019	49,421	$594	$12.60	$8.26 - $16.67
Q2 2019	122,124	$1,479	$11.06	$8.88 - $13.14
Q1 2019	45,877	$577	$8.83	$6.38 - $14.36
Q4 2018	57,178	$385	$7.93	$5.49 - $10.50
Q3 2018	144,519	$1,487	$8.61	$6.57 - $11.90
Q1 2018	32,800	$282	$18.83	$7.85 - $23.97
Q4 2017	57,776	$1,202	$17.74	$14.10 - $21.31