PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2024

Shares 5,505 Value ($000) $212 Avg Close $43.60 Range $33.31 - $48.89

Q2 2022

Shares 12,540 Value ($000) $99 Avg Close $12.09 Range $6.91 - $25.76

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2024	5,505	$212	$43.60	$33.31 - $48.89
Q2 2022	12,540	$99	$12.09	$6.91 - $25.76