PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q3 2024

Shares 12,100 Value ($000) $545 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 116,600 Value ($000) $4,040 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 196,700 Value ($000) $5,691 Avg Close $27.21 Range $21.43 - $33.34

Q4 2023

Shares 222,000 Value ($000) $5,090 Avg Close $17.50 Range $13.72 - $23.88

Q3 2023

Shares 316,900 Value ($000) $5,286 Avg Close $19.40 Range $16.33 - $26.81

Q2 2023

Shares 412,100 Value ($000) $11,382 Avg Close $25.03 Range $17.64 - $30.10

Q1 2023

Shares 449,800 Value ($000) $10,345 Avg Close $16.79 Range $10.62 - $25.69

Q4 2022

Shares 603,500 Value ($000) $6,584 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 407,300 Value ($000) $3,434 Avg Close $9.46 Range $7.68 - $11.97

Q2 2022

Shares 518,400 Value ($000) $4,101 Avg Close $12.09 Range $6.91 - $25.76

Q1 2022

Shares 214,700 Value ($000) $5,084 Avg Close $28.17 Range $22.56 - $37.05

Q4 2021

Shares 38,800 Value ($000) $1,327 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 145,300 Value ($000) $2,575 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 256,075 Value ($000) $11,493 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 346,675 Value ($000) $8,979 Avg Close $25.31 Range $18.82 - $32.10

Q4 2020

Shares 367,275 Value ($000) $7,404 Avg Close $21.52 Range $17.44 - $25.65

Q3 2020

Shares 355,175 Value ($000) $6,944 Avg Close $18.76 Range $14.16 - $23.25

Q2 2020

Shares 419,200 Value ($000) $7,403 Avg Close $12.55 Range $6.00 - $19.67

Q1 2020

Shares 224,700 Value ($000) $1,586 Avg Close $7.49 Range $5.30 - $9.30

Q4 2019

Shares 319,000 Value ($000) $2,249 Avg Close $9.93 Range $4.47 - $13.77

Q3 2019

Shares 152,200 Value ($000) $1,828 Avg Close $12.60 Range $8.26 - $16.67

Q2 2019

Shares 125,000 Value ($000) $1,514 Avg Close $11.06 Range $8.88 - $13.14

Q1 2019

Shares 93,800 Value ($000) $1,179 Avg Close $8.83 Range $6.38 - $14.36

Q4 2018

Shares 96,200 Value ($000) $647 Avg Close $7.93 Range $5.49 - $10.50

Q3 2018

Shares 143,100 Value ($000) $1,472 Avg Close $8.61 Range $6.57 - $11.90

Q2 2018

Shares 157,900 Value ($000) $1,061 Avg Close $7.68 Range $5.50 - $9.44

Q1 2018

Shares 47,100 Value ($000) $405 Avg Close $18.83 Range $7.85 - $23.97

Q4 2017

Shares 17,400 Value ($000) $362 Avg Close $17.74 Range $14.10 - $21.31

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2024	12,100	$545	$40.40	$32.50 - $48.00
Q2 2024	116,600	$4,040	$29.29	$24.22 - $35.96
Q1 2024	196,700	$5,691	$27.21	$21.43 - $33.34
Q4 2023	222,000	$5,090	$17.50	$13.72 - $23.88
Q3 2023	316,900	$5,286	$19.40	$16.33 - $26.81
Q2 2023	412,100	$11,382	$25.03	$17.64 - $30.10
Q1 2023	449,800	$10,345	$16.79	$10.62 - $25.69
Q4 2022	603,500	$6,584	$8.44	$7.24 - $11.46
Q3 2022	407,300	$3,434	$9.46	$7.68 - $11.97
Q2 2022	518,400	$4,101	$12.09	$6.91 - $25.76
Q1 2022	214,700	$5,084	$28.17	$22.56 - $37.05
Q4 2021	38,800	$1,327	$31.61	$17.26 - $38.11
Q3 2021	145,300	$2,575	$42.63	$12.80 - $50.54
Q2 2021	256,075	$11,493	$33.01	$24.14 - $45.93
Q1 2021	346,675	$8,979	$25.31	$18.82 - $32.10
Q4 2020	367,275	$7,404	$21.52	$17.44 - $25.65
Q3 2020	355,175	$6,944	$18.76	$14.16 - $23.25
Q2 2020	419,200	$7,403	$12.55	$6.00 - $19.67
Q1 2020	224,700	$1,586	$7.49	$5.30 - $9.30
Q4 2019	319,000	$2,249	$9.93	$4.47 - $13.77
Q3 2019	152,200	$1,828	$12.60	$8.26 - $16.67
Q2 2019	125,000	$1,514	$11.06	$8.88 - $13.14
Q1 2019	93,800	$1,179	$8.83	$6.38 - $14.36
Q4 2018	96,200	$647	$7.93	$5.49 - $10.50
Q3 2018	143,100	$1,472	$8.61	$6.57 - $11.90
Q2 2018	157,900	$1,061	$7.68	$5.50 - $9.44
Q1 2018	47,100	$405	$18.83	$7.85 - $23.97
Q4 2017	17,400	$362	$17.74	$14.10 - $21.31