PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 7,598 Value ($000) $505 Avg Close $56.84 Range $49.38 - $68.26

Q2 2025

Shares 26,994 Value ($000) $1,492 Avg Close $47.99 Range $39.60 - $57.70

Q1 2025

Shares 16,114 Value ($000) $779 Avg Close $41.90 Range $33.70 - $60.60

Q2 2024

Shares 8,971 Value ($000) $311 Avg Close $29.29 Range $24.22 - $35.96

Q4 2023

Shares 11,806 Value ($000) $271 Avg Close $17.50 Range $13.72 - $23.88

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	7,598	$505	$56.84	$49.38 - $68.26
Q2 2025	26,994	$1,492	$47.99	$39.60 - $57.70
Q1 2025	16,114	$779	$41.90	$33.70 - $60.60
Q2 2024	8,971	$311	$29.29	$24.22 - $35.96
Q4 2023	11,806	$271	$17.50	$13.72 - $23.88