PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

Sofinnova Investments, Inc.'s Holding History (CIK: 0001631134)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 547,441 Value ($000) $12,963 Avg Close $28.17 Range $22.56 - $37.05

Q4 2021

Shares 482,257 Value ($000) $16,493 Avg Close $31.61 Range $17.26 - $38.11

Q3 2021

Shares 297,709 Value ($000) $5,275 Avg Close $42.63 Range $12.80 - $50.54

Q2 2021

Shares 449,082 Value ($000) $20,155 Avg Close $33.01 Range $24.14 - $45.93

Q1 2021

Shares 654,900 Value ($000) $16,962 Avg Close $25.31 Range $18.82 - $32.10

Q3 2020

Shares 357,769 Value ($000) $6,994 Avg Close $18.76 Range $14.16 - $23.25

Q2 2020

Shares 326,064 Value ($000) $5,758 Avg Close $12.55 Range $6.00 - $19.67

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	547,441	$12,963	$28.17	$22.56 - $37.05
Q4 2021	482,257	$16,493	$31.61	$17.26 - $38.11
Q3 2021	297,709	$5,275	$42.63	$12.80 - $50.54
Q2 2021	449,082	$20,155	$33.01	$24.14 - $45.93
Q1 2021	654,900	$16,962	$25.31	$18.82 - $32.10
Q3 2020	357,769	$6,994	$18.76	$14.16 - $23.25
Q2 2020	326,064	$5,758	$12.55	$6.00 - $19.67