PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

Holocene Advisors, LP's Holding History (CIK: 0001700574)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 210,019 Value ($000) $18,343 Avg Close $81.85 Range $62.24 - $96.54

Q2 2025

Shares 530,326 Value ($000) $29,311 Avg Close $47.99 Range $39.60 - $57.70

Q2 2023

Shares 802,531 Value ($000) $22,166 Avg Close $25.03 Range $17.64 - $30.10

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	210,019	$18,343	$81.85	$62.24 - $96.54
Q2 2025	530,326	$29,311	$47.99	$39.60 - $57.70
Q2 2023	802,531	$22,166	$25.03	$17.64 - $30.10