PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

Qube Research & Technologies Ltd's Holding History (CIK: 0001729829)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 153,876 Value ($000) $13,440 Avg Close $81.85 Range $62.24 - $96.54

Q2 2025

Shares 68,983 Value ($000) $3,813 Avg Close $47.99 Range $39.60 - $57.70

Q1 2025

Shares 343,411 Value ($000) $16,607 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 312,319 Value ($000) $12,056 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 322,989 Value ($000) $14,535 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 453,152 Value ($000) $15,702 Avg Close $29.29 Range $24.22 - $35.96

Q1 2024

Shares 62,155 Value ($000) $1,798 Avg Close $27.21 Range $21.43 - $33.34

Q3 2023

Shares 91,735 Value ($000) $1,530 Avg Close $19.40 Range $16.33 - $26.81

Q4 2022

Shares 135,706 Value ($000) $1,481 Avg Close $8.44 Range $7.24 - $11.46

Q3 2022

Shares 91,276 Value ($000) $769 Avg Close $9.46 Range $7.68 - $11.97

Q1 2021

Shares 13,465 Value ($000) $349 Avg Close $25.31 Range $18.82 - $32.10

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	153,876	$13,440	$81.85	$62.24 - $96.54
Q2 2025	68,983	$3,813	$47.99	$39.60 - $57.70
Q1 2025	343,411	$16,607	$41.90	$33.70 - $60.60
Q4 2024	312,319	$12,056	$43.60	$33.31 - $48.89
Q3 2024	322,989	$14,535	$40.40	$32.50 - $48.00
Q2 2024	453,152	$15,702	$29.29	$24.22 - $35.96
Q1 2024	62,155	$1,798	$27.21	$21.43 - $33.34
Q3 2023	91,735	$1,530	$19.40	$16.33 - $26.81
Q4 2022	135,706	$1,481	$8.44	$7.24 - $11.46
Q3 2022	91,276	$769	$9.46	$7.68 - $11.97
Q1 2021	13,465	$349	$25.31	$18.82 - $32.10