PROTAGONIST THERAPEUTICS INC

Ticker: PTGX CUSIP: 74366E102 Class: Common Stock

Pictet Asset Management Holding SA's Holding History (CIK: 0001993888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 529,631 Value ($000) $46,258 Avg Close $81.85 Range $62.24 - $96.54

Q3 2025

Shares 822,212 Value ($000) $54,620 Avg Close $56.84 Range $49.38 - $68.26

Q2 2025

Shares 751,977 Value ($000) $41,562 Avg Close $47.99 Range $39.60 - $57.70

Q1 2025

Shares 295,593 Value ($000) $14,295 Avg Close $41.90 Range $33.70 - $60.60

Q4 2024

Shares 296,511 Value ($000) $11,445 Avg Close $43.60 Range $33.31 - $48.89

Q3 2024

Shares 7,298 Value ($000) $328 Avg Close $40.40 Range $32.50 - $48.00

Q2 2024

Shares 5,848 Value ($000) $203 Avg Close $29.29 Range $24.22 - $35.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	529,631	$46,258	$81.85	$62.24 - $96.54
Q3 2025	822,212	$54,620	$56.84	$49.38 - $68.26
Q2 2025	751,977	$41,562	$47.99	$39.60 - $57.70
Q1 2025	295,593	$14,295	$41.90	$33.70 - $60.60
Q4 2024	296,511	$11,445	$43.60	$33.31 - $48.89
Q3 2024	7,298	$328	$40.40	$32.50 - $48.00
Q2 2024	5,848	$203	$29.29	$24.22 - $35.96