PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

RTW INVESTMENTS, LP's Holding History (CIK: 0001493215)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 313,466 Value ($000) $1,016 Avg Close — Range —
Q3 2018
Shares 1,129,121 Value ($000) $2,721 Avg Close — Range —
Q2 2018
Shares 1,077,408 Value ($000) $3,006 Avg Close — Range —
Q1 2018
Shares 1,104,940 Value ($000) $5,248 Avg Close — Range —
Q4 2017
Shares 1,500,000 Value ($000) $8,745 Avg Close — Range —