PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2020
Shares 2,536,600 Value ($000) $2,892 Avg Close — Range —
Q4 2019
Shares 2,536,600 Value ($000) $5,783 Avg Close — Range —