PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 150,000 Value ($000) $1,839 Avg Close — Range —
Q3 2016
Shares 152,000 Value ($000) $2,370 Avg Close — Range —
Q2 2016
Shares 105,000 Value ($000) $1,274 Avg Close — Range —