PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

FRED ALGER MANAGEMENT, LLC's Holding History (CIK: 0000003520)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021

Shares 2,470,965 Value ($000) $17,322 Avg Close $7.49 Range $6.48 - $9.48

Q2 2021

Shares 2,985,976 Value ($000) $27,411 Avg Close $10.13 Range $8.74 - $11.95

Q1 2021

Shares 3,626,637 Value ($000) $35,251 Avg Close $11.17 Range $9.19 - $14.14

Q4 2020

Shares 3,416,003 Value ($000) $35,048 Avg Close $10.13 Range $7.48 - $13.16

Q3 2020

Shares 3,332,523 Value ($000) $33,625 Avg Close $10.18 Range $9.04 - $12.90

Q2 2020

Shares 2,474,029 Value ($000) $25,804 Avg Close $10.35 Range $6.81 - $13.78

Q1 2020

Shares 2,334,967 Value ($000) $19,707 Avg Close $9.72 Range $5.50 - $15.00

Q4 2019

Shares 1,771,185 Value ($000) $15,498 Avg Close $8.28 Range $6.26 - $11.10

Q3 2019

Shares 1,666,679 Value ($000) $17,942 Avg Close $10.80 Range $8.45 - $13.35

Q2 2019

Shares 1,186,936 Value ($000) $15,086 Avg Close $23.03 Range $12.22 - $36.75

Q1 2019

Shares 1,190,675 Value ($000) $46,186 Avg Close $30.54 Range $19.86 - $43.90

Q4 2018

Shares 822,041 Value ($000) $16,729 Avg Close $30.01 Range $17.60 - $47.14

Q3 2018

Shares 901,182 Value ($000) $41,319 Avg Close $48.21 Range $40.45 - $60.95

Q2 2018

Shares 384,838 Value ($000) $22,763 Avg Close $57.95 Range $47.00 - $68.90

Q1 2018

Shares 259,023 Value ($000) $17,627 Avg Close $74.88 Range $56.15 - $101.50

Q4 2017

Shares 190,935 Value ($000) $18,874 Avg Close $111.90 Range $92.36 - $136.90

Q3 2017

Shares 187,118 Value ($000) $22,407 Avg Close $93.01 Range $71.14 - $120.85

Q2 2017

Shares 207,884 Value ($000) $18,169 Avg Close $55.94 Range $28.35 - $92.00

Q1 2017

Shares 297,414 Value ($000) $11,064 Avg Close $36.49 Range $28.95 - $45.44

Q1 2015

Shares 94,166 Value ($000) $22,233 Avg Close $213.77 Range $183.50 - $252.92

Q4 2014

Shares 206,698 Value ($000) $39,122 Avg Close $221.87 Range $181.60 - $255.43

Q3 2014

Shares 161,904 Value ($000) $38,625 Avg Close $205.34 Range $57.25 - $279.37

Q2 2014

Shares 223,290 Value ($000) $14,737 Avg Close $71.11 Range $53.63 - $118.22

Q1 2014

Shares 142,557 Value ($000) $14,846 Avg Close $117.54 Range $97.31 - $143.65

Q4 2013

Shares 121,076 Value ($000) $12,535 Avg Close $58.69 Range $33.70 - $112.46

Q3 2013

Shares 1,330 Value ($000) $71 Avg Close $53.90 Range $44.39 - $62.66

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2021	2,470,965	$17,322	$7.49	$6.48 - $9.48
Q2 2021	2,985,976	$27,411	$10.13	$8.74 - $11.95
Q1 2021	3,626,637	$35,251	$11.17	$9.19 - $14.14
Q4 2020	3,416,003	$35,048	$10.13	$7.48 - $13.16
Q3 2020	3,332,523	$33,625	$10.18	$9.04 - $12.90
Q2 2020	2,474,029	$25,804	$10.35	$6.81 - $13.78
Q1 2020	2,334,967	$19,707	$9.72	$5.50 - $15.00
Q4 2019	1,771,185	$15,498	$8.28	$6.26 - $11.10
Q3 2019	1,666,679	$17,942	$10.80	$8.45 - $13.35
Q2 2019	1,186,936	$15,086	$23.03	$12.22 - $36.75
Q1 2019	1,190,675	$46,186	$30.54	$19.86 - $43.90
Q4 2018	822,041	$16,729	$30.01	$17.60 - $47.14
Q3 2018	901,182	$41,319	$48.21	$40.45 - $60.95
Q2 2018	384,838	$22,763	$57.95	$47.00 - $68.90
Q1 2018	259,023	$17,627	$74.88	$56.15 - $101.50
Q4 2017	190,935	$18,874	$111.90	$92.36 - $136.90
Q3 2017	187,118	$22,407	$93.01	$71.14 - $120.85
Q2 2017	207,884	$18,169	$55.94	$28.35 - $92.00
Q1 2017	297,414	$11,064	$36.49	$28.95 - $45.44
Q1 2015	94,166	$22,233	$213.77	$183.50 - $252.92
Q4 2014	206,698	$39,122	$221.87	$181.60 - $255.43
Q3 2014	161,904	$38,625	$205.34	$57.25 - $279.37
Q2 2014	223,290	$14,737	$71.11	$53.63 - $118.22
Q1 2014	142,557	$14,846	$117.54	$97.31 - $143.65
Q4 2013	121,076	$12,535	$58.69	$33.70 - $112.46
Q3 2013	1,330	$71	$53.90	$44.39 - $62.66