PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

TOCQUEVILLE ASSET MANAGEMENT L.P.'s Holding History (CIK: 0000883961)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015

Shares 2,650 Value ($000) $208 Avg Close $78.49 Range $56.11 - $94.93

Q3 2015

Shares 4,165 Value ($000) $314 Avg Close $94.57 Range $70.39 - $119.36

Q2 2015

Shares 4,165 Value ($000) $486 Avg Close $181.09 Range $112.32 - $244.90

Q1 2015

Shares 6,465 Value ($000) $1,526 Avg Close $213.77 Range $183.50 - $252.92

Q4 2014

Shares 6,965 Value ($000) $1,318 Avg Close $221.87 Range $181.60 - $255.43

Q3 2014

Shares 8,305 Value ($000) $1,981 Avg Close $205.34 Range $57.25 - $279.37

Q2 2014

Shares 1,900 Value ($000) $125 Avg Close $71.11 Range $53.63 - $118.22

Q1 2014

Shares 3,400 Value ($000) $354 Avg Close $117.54 Range $97.31 - $143.65

Q4 2013

Shares 1,300 Value ($000) $135 Avg Close $58.69 Range $33.70 - $112.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2015	2,650	$208	$78.49	$56.11 - $94.93
Q3 2015	4,165	$314	$94.57	$70.39 - $119.36
Q2 2015	4,165	$486	$181.09	$112.32 - $244.90
Q1 2015	6,465	$1,526	$213.77	$183.50 - $252.92
Q4 2014	6,965	$1,318	$221.87	$181.60 - $255.43
Q3 2014	8,305	$1,981	$205.34	$57.25 - $279.37
Q2 2014	1,900	$125	$71.11	$53.63 - $118.22
Q1 2014	3,400	$354	$117.54	$97.31 - $143.65
Q4 2013	1,300	$135	$58.69	$33.70 - $112.46