PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 322,000 Value ($000) $21,912 Avg Close $74.88 Range $56.15 - $101.50
Q4 2017
Shares 2,222,500 Value ($000) $219,694 Avg Close $111.90 Range $92.36 - $136.90
Q3 2017
Shares 2,550,000 Value ($000) $305,363 Avg Close $93.01 Range $71.14 - $120.85
Q2 2017
Shares 3,350,000 Value ($000) $292,790 Avg Close $55.94 Range $28.35 - $92.00
Q1 2017
Shares 5,686,668 Value ($000) $211,544 Avg Close $36.49 Range $28.95 - $45.44
Q4 2016
Shares 5,686,668 Value ($000) $174,581 Avg Close $43.24 Range $29.85 - $68.05
Q3 2016
Shares 5,686,668 Value ($000) $381,291 Avg Close $50.56 Range $28.14 - $73.27
Q2 2016
Shares 5,686,668 Value ($000) $169,406 Avg Close $31.26 Range $19.74 - $39.67
Q1 2016
Shares 5,686,668 Value ($000) $167,017 Avg Close $45.19 Range $25.20 - $77.99
Q4 2015
Shares 5,686,668 Value ($000) $445,835 Avg Close $78.49 Range $56.11 - $94.93
Q3 2015
Shares 5,686,668 Value ($000) $428,527 Avg Close $94.57 Range $70.39 - $119.36
Q2 2015
Shares 5,686,668 Value ($000) $663,918 Avg Close $181.09 Range $112.32 - $244.90
Q1 2015
Shares 5,686,668 Value ($000) $1,342,679 Avg Close $213.77 Range $183.50 - $252.92
Q4 2014
Shares 5,686,668 Value ($000) $1,076,316 Avg Close $221.87 Range $181.60 - $255.43
Q3 2014
Shares 5,686,668 Value ($000) $1,356,668 Avg Close $205.34 Range $57.25 - $279.37
Q2 2014
Shares 5,686,668 Value ($000) $375,320 Avg Close $71.11 Range $53.63 - $118.22
Q1 2014
Shares 5,686,668 Value ($000) $592,210 Avg Close $117.54 Range $97.31 - $143.65
Q4 2013
Shares 5,686,668 Value ($000) $588,741 Avg Close $58.69 Range $33.70 - $112.46
Q3 2013
Shares 5,242,519 Value ($000) $281,314 Avg Close $53.90 Range $44.39 - $62.66
Q2 2013
Shares 5,242,519 Value ($000) $232,611 Avg Close $35.25 Range $27.40 - $45.69
Q1 2013
Shares 5,242,519 Value ($000) $175,048 Avg Close $25.18 Range $18.47 - $34.98