PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 162,351 Value ($000) $966 Avg Close $5.31 Range $4.58 - $6.27

Q3 2025

Shares 56,126 Value ($000) $298 Avg Close $4.24 Range $3.03 - $6.07

Q2 2025

Shares 190,621 Value ($000) $654 Avg Close $3.19 Range $2.58 - $3.82

Q1 2025

Shares 192,800 Value ($000) $571 Avg Close $3.13 Range $2.69 - $4.06

Q4 2024

Shares 181,471 Value ($000) $553 Avg Close $2.91 Range $2.32 - $3.51

Q3 2024

Shares 49,555 Value ($000) $126 Avg Close $3.03 Range $2.23 - $4.13

Q2 2024

Shares 34,298 Value ($000) $112 Avg Close $4.39 Range $2.81 - $6.06

Q1 2024

Shares 81,694 Value ($000) $433 Avg Close $5.38 Range $4.12 - $7.73

Q4 2023

Shares 215,172 Value ($000) $932 Avg Close $3.31 Range $2.13 - $4.59

Q3 2023

Shares 107,738 Value ($000) $283 Avg Close $3.41 Range $2.57 - $4.19

Q2 2023

Shares 106,073 Value ($000) $374 Avg Close $3.12 Range $2.53 - $3.75

Q1 2023

Shares 208,149 Value ($000) $643 Avg Close $3.77 Range $2.13 - $4.89

Q4 2022

Shares 283,950 Value ($000) $1,201 Avg Close $3.45 Range $2.08 - $5.16

Q3 2022

Shares 83,607 Value ($000) $198 Avg Close $2.92 Range $2.23 - $4.07

Q2 2022

Shares 154,204 Value ($000) $439 Avg Close $2.49 Range $1.60 - $3.42

Q1 2022

Shares 166,451 Value ($000) $479 Avg Close $2.59 Range $2.06 - $3.38

Q3 2021

Shares 15,920 Value ($000) $112 Avg Close $7.49 Range $6.48 - $9.48

Q2 2021

Shares 55,558 Value ($000) $510 Avg Close $10.13 Range $8.74 - $11.95

Q2 2019

Shares 232,772 Value ($000) $2,959 Avg Close $23.03 Range $12.22 - $36.75

Q1 2019

Shares 127,657 Value ($000) $4,952 Avg Close $30.54 Range $19.86 - $43.90

Q4 2018

Shares 124,412 Value ($000) $2,532 Avg Close $30.01 Range $17.60 - $47.14

Q3 2017

Shares 1,786 Value ($000) $214 Avg Close $93.01 Range $71.14 - $120.85

Q2 2015

Shares 19,201 Value ($000) $2,242 Avg Close $181.09 Range $112.32 - $244.90

Q3 2014

Shares 9,497 Value ($000) $2,266 Avg Close $205.34 Range $57.25 - $279.37

Q2 2013

Shares 14,073 Value ($000) $624 Avg Close $35.25 Range $27.40 - $45.69

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	162,351	$966	$5.31	$4.58 - $6.27
Q3 2025	56,126	$298	$4.24	$3.03 - $6.07
Q2 2025	190,621	$654	$3.19	$2.58 - $3.82
Q1 2025	192,800	$571	$3.13	$2.69 - $4.06
Q4 2024	181,471	$553	$2.91	$2.32 - $3.51
Q3 2024	49,555	$126	$3.03	$2.23 - $4.13
Q2 2024	34,298	$112	$4.39	$2.81 - $6.06
Q1 2024	81,694	$433	$5.38	$4.12 - $7.73
Q4 2023	215,172	$932	$3.31	$2.13 - $4.59
Q3 2023	107,738	$283	$3.41	$2.57 - $4.19
Q2 2023	106,073	$374	$3.12	$2.53 - $3.75
Q1 2023	208,149	$643	$3.77	$2.13 - $4.89
Q4 2022	283,950	$1,201	$3.45	$2.08 - $5.16
Q3 2022	83,607	$198	$2.92	$2.23 - $4.07
Q2 2022	154,204	$439	$2.49	$1.60 - $3.42
Q1 2022	166,451	$479	$2.59	$2.06 - $3.38
Q3 2021	15,920	$112	$7.49	$6.48 - $9.48
Q2 2021	55,558	$510	$10.13	$8.74 - $11.95
Q2 2019	232,772	$2,959	$23.03	$12.22 - $36.75
Q1 2019	127,657	$4,952	$30.54	$19.86 - $43.90
Q4 2018	124,412	$2,532	$30.01	$17.60 - $47.14
Q3 2017	1,786	$214	$93.01	$71.14 - $120.85
Q2 2015	19,201	$2,242	$181.09	$112.32 - $244.90
Q3 2014	9,497	$2,266	$205.34	$57.25 - $279.37
Q2 2013	14,073	$624	$35.25	$27.40 - $45.69