PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 745,541 Value ($000) $2,557 Avg Close $3.19 Range $2.58 - $3.82

Q1 2019

Shares 2,170,423 Value ($000) $84,191 Avg Close $30.54 Range $19.86 - $43.90

Q4 2018

Shares 1,861,944 Value ($000) $37,891 Avg Close $30.01 Range $17.60 - $47.14

Q3 2018

Shares 2,146,460 Value ($000) $98,415 Avg Close $48.21 Range $40.45 - $60.95

Q2 2018

Shares 3,302,021 Value ($000) $195,315 Avg Close $57.95 Range $47.00 - $68.90

Q1 2018

Shares 4,482,306 Value ($000) $304,791 Avg Close $74.88 Range $56.15 - $101.50

Q4 2017

Shares 4,355,643 Value ($000) $430,555 Avg Close $111.90 Range $92.36 - $136.90

Q3 2017

Shares 1,890,901 Value ($000) $226,435 Avg Close $93.01 Range $71.14 - $120.85

Q2 2017

Shares 1,857,631 Value ($000) $162,302 Avg Close $55.94 Range $28.35 - $92.00

Q3 2015

Shares 2,379 Value ($000) $179 Avg Close $94.57 Range $70.39 - $119.36

Q2 2015

Shares 2,379 Value ($000) $277 Avg Close $181.09 Range $112.32 - $244.90

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	745,541	$2,557	$3.19	$2.58 - $3.82
Q1 2019	2,170,423	$84,191	$30.54	$19.86 - $43.90
Q4 2018	1,861,944	$37,891	$30.01	$17.60 - $47.14
Q3 2018	2,146,460	$98,415	$48.21	$40.45 - $60.95
Q2 2018	3,302,021	$195,315	$57.95	$47.00 - $68.90
Q1 2018	4,482,306	$304,791	$74.88	$56.15 - $101.50
Q4 2017	4,355,643	$430,555	$111.90	$92.36 - $136.90
Q3 2017	1,890,901	$226,435	$93.01	$71.14 - $120.85
Q2 2017	1,857,631	$162,302	$55.94	$28.35 - $92.00
Q3 2015	2,379	$179	$94.57	$70.39 - $119.36
Q2 2015	2,379	$277	$181.09	$112.32 - $244.90