PUMA BIOTECHNOLOGY INC

Ticker: PBYI CUSIP: 74587V107 Class: Common Stock

Sofinnova Investments, Inc.'s Holding History (CIK: 0001631134)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 344,917 Value ($000) $3,353 Avg Close $11.17 Range $9.19 - $14.14

Q4 2020

Shares 629,650 Value ($000) $6,460 Avg Close $10.13 Range $7.48 - $13.16

Q3 2020

Shares 475,982 Value ($000) $4,803 Avg Close $10.18 Range $9.04 - $12.90

Q2 2020

Shares 1,197,630 Value ($000) $12,491 Avg Close $10.35 Range $6.81 - $13.78

Q1 2020

Shares 638,026 Value ($000) $5,385 Avg Close $9.72 Range $5.50 - $15.00

Q4 2018

Shares 190,627 Value ($000) $3,879 Avg Close $30.01 Range $17.60 - $47.14

Q3 2018

Shares 336,835 Value ($000) $15,444 Avg Close $48.21 Range $40.45 - $60.95

Q2 2018

Shares 6,384 Value ($000) $378 Avg Close $57.95 Range $47.00 - $68.90

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	344,917	$3,353	$11.17	$9.19 - $14.14
Q4 2020	629,650	$6,460	$10.13	$7.48 - $13.16
Q3 2020	475,982	$4,803	$10.18	$9.04 - $12.90
Q2 2020	1,197,630	$12,491	$10.35	$6.81 - $13.78
Q1 2020	638,026	$5,385	$9.72	$5.50 - $15.00
Q4 2018	190,627	$3,879	$30.01	$17.60 - $47.14
Q3 2018	336,835	$15,444	$48.21	$40.45 - $60.95
Q2 2018	6,384	$378	$57.95	$47.00 - $68.90