| ORBIMED ADVISORS LLC | 2,252,987 | $7,480 |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | $6,946 |
| Carlyle Group Inc. | 1,102,741 | $3,617 |
| ACORN CAPITAL ADVISORS, LLC | 493,425 | $1,638 |
| VANGUARD GROUP INC | 321,051 | $1,066 |
| ARCH Venture Management, LLC | 320,482 | $1,064 |
| Pfizer Inc | 277,777 | $922 |
| Sanofi | 244,083 | $810 |
| Opaleye Management Inc. | 213,363 | $708 |
| GEODE CAPITAL MANAGEMENT, LLC | 106,113 | $352 |
| RENAISSANCE TECHNOLOGIES LLC | 99,600 | $331 |
| BlackRock, Inc. | 59,932 | $199 |
| MILLENNIUM MANAGEMENT LLC | 51,268 | $170 |
| Monaco Asset Management SAM | 50,919 | $169 |
| ACADIAN ASSET MANAGEMENT LLC | 48,373 | $0 |
| TWO SIGMA INVESTMENTS, LP | 46,825 | $155 |
| CITADEL ADVISORS LLC | 45,728 | $152 |
| Affinity Asset Advisors, LLC | 27,777 | $92 |
| JANE STREET GROUP, LLC | 25,374 | $84 |
| NORTHERN TRUST CORP | 25,033 | $83 |
| HRT FINANCIAL LP | 24,698 | $0 |
| STATE STREET CORP | 21,237 | $71 |
| XTX Topco Ltd | 20,353 | $68 |
| ADAR1 Capital Management, LLC | 20,000 | $66 |
| Scientech Research LLC | 15,510 | $51 |
| UBS Group AG | 13,606 | $45 |
| MORGAN STANLEY | 5,478 | $18 |
| EverSource Wealth Advisors, LLC | 4,640 | $15 |
| FMR LLC | 3,364 | $11 |
| FEDERATED HERMES, INC. | 2,273 | $8 |
| Global Retirement Partners, LLC | 1,500 | $5 |
| SRS Capital Advisors, Inc. | 1,111 | $4 |
| BANK OF AMERICA CORP /DE/ | 1,035 | $3 |
| Tower Research Capital LLC (TRC) | 976 | $3 |
| Rockefeller Capital Management L.P. | 577 | $2 |
| JONES FINANCIAL COMPANIES LLLP | 500 | $2 |
| Russell Investments Group, Ltd. | 454 | $2 |
| JPMORGAN CHASE & CO | 324 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 308 | $1 |
| ROYAL BANK OF CANADA | 235 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 166 | $1 |
| SBI Securities Co., Ltd. | 157 | $1 |
| OSAIC HOLDINGS, INC. | 132 | $0 |
| Allworth Financial LP | 98 | $0 |
| Federation des caisses Desjardins du Quebec | 70 | $0 |
| CWM, LLC | 54 | $0 |
| GROUP ONE TRADING, L.P. | 34 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 30 | $0 |
| BARCLAYS PLC | 19 | $0 |
| HARBOUR INVESTMENTS, INC. | 11 | $0 |
| AdvisorNet Financial, Inc | 2 | $0 |
| DANSKE BANK A/S | 1 | $0 |