RAPPORT THERAPEUTICS INC

Ticker: RAPP CUSIP: 75383L102 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 50,619 Value ($000) $1,536 Avg Close $27.68 Range $23.75 - $32.36

Q3 2025

Shares 21,500 Value ($000) $639 Avg Close $17.84 Range $11.05 - $42.27

Q2 2025

Shares 19,743 Value ($000) $224 Avg Close $10.61 Range $7.73 - $14.79

Q1 2025

Shares 33,757 Value ($000) $339 Avg Close $12.98 Range $6.43 - $19.75

Q2 2024

Shares 13,000 Value ($000) $302 Avg Close $23.15 Range $18.00 - $27.11

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	50,619	$1,536	$27.68	$23.75 - $32.36
Q3 2025	21,500	$639	$17.84	$11.05 - $42.27
Q2 2025	19,743	$224	$10.61	$7.73 - $14.79
Q1 2025	33,757	$339	$12.98	$6.43 - $19.75
Q2 2024	13,000	$302	$23.15	$18.00 - $27.11