| TRV GP V, LLC | 7,135,233 | $216,483 |
| FMR LLC | 7,111,865 | $215,774 |
| ARCH Venture Management, LLC | 3,728,738 | $113,130 |
| Capital International Investors | 3,402,529 | $103,233 |
| Cormorant Asset Management, LP | 3,027,521 | $91,855 |
| GOLDMAN SACHS GROUP INC | 3,001,879 | $91,077 |
| BlackRock, Inc. | 2,431,862 | $73,783 |
| Sofinnova Investments, Inc. | 1,904,408 | $57,780 |
| VANGUARD GROUP INC | 1,817,757 | $55,151 |
| JOHNSON & JOHNSON | 1,784,517 | $54,142 |
| BAKER BROS. ADVISORS LP | 1,547,090 | $46,939 |
| Vestal Point Capital, LP | 1,110,000 | $33,677 |
| Polar Capital Holdings Plc | 1,004,728 | $30,483 |
| TRV GP VI, LLC | 969,218 | $29,406 |
| UBS ASSET MANAGEMENT AMERICAS INC | 952,371 | $28,895 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 881,609 | $27 |
| ALLIANCEBERNSTEIN L.P. | 788,411 | $23,920 |
| STATE STREET CORP | 714,821 | $21,688 |
| Siren, L.L.C. | 708,469 | $21,495 |
| GEODE CAPITAL MANAGEMENT, LLC | 694,734 | $21,081 |
| PERCEPTIVE ADVISORS LLC | 673,923 | $20,447 |
| Invesco Ltd. | 267,120 | $8,104 |
| PRUDENTIAL FINANCIAL INC | 254,967 | $7,736 |
| Burkehill Global Management, LP | 250,000 | $7,585 |
| D. E. Shaw & Co., Inc. | 247,315 | $7,504 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 244,391 | $7,415 |
| T. Rowe Price Investment Management, Inc. | 234,769 | $7 |
| UBS Group AG | 226,360 | $6,868 |
| NORTHERN TRUST CORP | 220,815 | $6,700 |
| MORGAN STANLEY | 210,331 | $6,381 |
| MILLENNIUM MANAGEMENT LLC | 201,825 | $6,123 |
| Ensign Peak Advisors, Inc | 194,200 | $5,892 |
| Sio Capital Management, LLC | 185,265 | $5,621 |
| KENNEDY CAPITAL MANAGEMENT LLC | 178,737 | $5,423 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | $4,551 |
| Artia Global Partners LP | 138,508 | $4,202 |
| RENAISSANCE TECHNOLOGIES LLC | 118,814 | $3,605 |
| TD Asset Management Inc | 115,190 | $3,495 |
| Swedbank AB | 113,200 | $3,434 |
| EAM Investors, LLC | 85,555 | $2,596 |
| DIMENSIONAL FUND ADVISORS LP | 83,487 | $2,533 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,659 | $2,407 |
| DAFNA Capital Management LLC | 75,000 | $2,276 |
| Bank of New York Mellon Corp | 74,081 | $2,248 |
| Nuveen, LLC | 70,946 | $2,153 |
| Voya Investment Management LLC | 66,149 | $2,007 |
| Trexquant Investment LP | 62,979 | $1,911 |
| Eversept Partners, LP | 59,233 | $1,797 |
| CITIGROUP INC | 56,484 | $1,714 |
| WELLINGTON MANAGEMENT GROUP LLP | 56,457 | $1,713 |
| Swiss National Bank | 54,600 | $1,657 |
| BARCLAYS PLC | 52,480 | $1,592 |
| TWO SIGMA INVESTMENTS, LP | 50,619 | $1,536 |
| AMERICAN CENTURY COMPANIES INC | 46,849 | $1,421 |
| ACADIAN ASSET MANAGEMENT LLC | 44,291 | $1 |
| ALPS ADVISORS INC | 39,139 | $1,187 |
| SECTORAL ASSET MANAGEMENT INC | 38,925 | $1,181 |
| ExodusPoint Capital Management, LP | 34,651 | $1,051 |
| BANK OF AMERICA CORP /DE/ | 34,553 | $1,048 |
| WELLS FARGO & COMPANY/MN | 32,109 | $974 |
| RHUMBLINE ADVISERS | 30,726 | $932 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,690 | $810 |
| Legal & General Group Plc | 22,384 | $679 |
| DEUTSCHE BANK AG\ | 21,535 | $653 |
| DARK FOREST CAPITAL MANAGEMENT LP | 21,074 | $639 |
| AQR CAPITAL MANAGEMENT LLC | 20,878 | $633 |
| SEI INVESTMENTS CO | 18,268 | $554 |
| PSP Research LLC | 17,506 | $531 |
| Brevan Howard Capital Management LP | 16,783 | $509 |
| MetLife Investment Management, LLC | 15,996 | $485 |
| JPMORGAN CHASE & CO | 15,129 | $459 |
| AMERIPRISE FINANCIAL INC | 14,794 | $449 |
| JANUS HENDERSON GROUP PLC | 13,800 | $419 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,249 | $402 |
| Allianz Asset Management GmbH | 13,200 | $400 |
| XTX Topco Ltd | 13,062 | $396 |
| GSA CAPITAL PARTNERS LLP | 12,733 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 12,353 | $375 |
| Creative Planning | 12,212 | $371 |
| China Universal Asset Management Co., Ltd. | 10,766 | $327 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,208 | $310 |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | $303 |
| SG Americas Securities, LLC | 9,673 | $0 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 9,659 | $293 |
| CANADA PENSION PLAN INVESTMENT BOARD | 9,100 | $276 |
| PROFUND ADVISORS LLC | 8,880 | $269 |
| Quadrature Capital Ltd | 8,837 | $268 |
| Virtus Investment Advisers, LLC | 8,789 | $267 |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,297 | $252 |
| CITADEL ADVISORS LLC | 8,099 | $246 |
| INTECH INVESTMENT MANAGEMENT LLC | 8,026 | $244 |
| Squarepoint Ops LLC | 7,859 | $238 |
| Rafferty Asset Management, LLC | 7,801 | $237 |
| Arizona State Retirement System | 7,726 | $234 |
| Police & Firemen's Retirement System of New Jersey | 7,471 | $227 |
| ProShare Advisors LLC | 7,308 | $222 |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | $221 |
| Susquehanna Portfolio Strategies, LLC | 7,031 | $213 |
| STIFEL FINANCIAL CORP | 6,823 | $207 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,690 | $180 |
| 42 other institutions | 50,179 | $1,434 |