REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018
Shares 595,501 Value ($000) $118 Avg Close — Range —
Q2 2018
Shares 119,989 Value ($000) $79 Avg Close — Range —
Q1 2018
Shares 128,989 Value ($000) $93 Avg Close — Range —
Q4 2017
Shares 137,589 Value ($000) $143 Avg Close — Range —
Q3 2017
Shares 43,589 Value ($000) $54 Avg Close — Range —
Q1 2017
Shares 118,341 Value ($000) $195 Avg Close — Range —
Q4 2016
Shares 321,200 Value ($000) $723 Avg Close — Range —
Q3 2016
Shares 645,000 Value ($000) $2,128 Avg Close — Range —
Q2 2015
Shares 57,000 Value ($000) $625 Avg Close — Range —