RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

FRED ALGER MANAGEMENT, LLC's Holding History (CIK: 0000003520)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,301 Value ($000) $996 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 12,335 Value ($000) $1,246 Avg Close $92.84 Range $62.84 - $106.52

Q4 2023

Shares 11,795 Value ($000) $542 Avg Close $31.55 Range $20.97 - $50.27

Q4 2022

Shares 19,988 Value ($000) $582 Avg Close $25.70 Range $21.57 - $30.90

Q3 2022

Shares 20,286 Value ($000) $497 Avg Close $18.60 Range $4.08 - $30.98

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,301	$996	$106.08	$95.27 - $122.20
Q3 2025	12,335	$1,246	$92.84	$62.84 - $106.52
Q4 2023	11,795	$542	$31.55	$20.97 - $50.27
Q4 2022	19,988	$582	$25.70	$21.57 - $30.90
Q3 2022	20,286	$497	$18.60	$4.08 - $30.98