| RA CAPITAL MANAGEMENT, L.P. | 6,666,837 | $713,618 |
| BlackRock, Inc. | 6,297,334 | $674,067 |
| VANGUARD GROUP INC | 6,210,916 | $664,816 |
| BAKER BROS. ADVISORS LP | 5,604,483 | $599,904 |
| PRIMECAP MANAGEMENT CO/CA/ | 3,478,669 | $372,357 |
| NEA Management Company, LLC | 2,909,956 | $311,482 |
| PERCEPTIVE ADVISORS LLC | 2,546,391 | $272,566 |
| STATE STREET CORP | 2,198,615 | $235,340 |
| GOLDMAN SACHS GROUP INC | 1,830,866 | $195,976 |
| FMR LLC | 1,706,317 | $182,644 |
| FEDERATED HERMES, INC. | 1,623,841 | $173,816 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,560,847 | $167 |
| JPMORGAN CHASE & CO | 1,423,989 | $152,424 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,375,729 | $147,283 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,285,222 | $137,570 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,267,158 | $135,637 |
| Polar Capital Holdings Plc | 1,185,392 | $126,884 |
| JANUS HENDERSON GROUP PLC | 1,126,125 | $120,591 |
| Checkpoint Capital L.P. | 992,200 | $106,205 |
| Capital Research Global Investors | 985,086 | $105,444 |
| ALLIANCEBERNSTEIN L.P. | 930,233 | $99,572 |
| JENNISON ASSOCIATES LLC | 918,567 | $98,323 |
| FRANKLIN RESOURCES INC | 695,735 | $74,471 |
| Rock Springs Capital Management LP | 695,010 | $74,394 |
| Woodline Partners LP | 688,779 | $73,727 |
| MORGAN STANLEY | 651,402 | $69,726 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,585 | $66,534 |
| LORD, ABBETT & CO. LLC | 619,542 | $66 |
| Pictet Asset Management Holding SA | 614,663 | $66,187 |
| UBS ASSET MANAGEMENT AMERICAS INC | 549,020 | $58,767 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532,447 | $56,993 |
| Clearbridge Investments, LLC | 506,109 | $54,174 |
| LOOMIS SAYLES & CO L P | 503,901 | $53,938 |
| Siren, L.L.C. | 499,975 | $53,517 |
| NORTHERN TRUST CORP | 488,216 | $52,259 |
| Integral Health Asset Management, LLC | 475,000 | $50,844 |
| Point72 Asset Management, L.P. | 429,420 | $45,965 |
| UBS Group AG | 427,236 | $45,731 |
| RENAISSANCE TECHNOLOGIES LLC | 341,193 | $36,521 |
| Opaleye Management Inc. | 330,000 | $35,323 |
| Qube Research & Technologies Ltd | 310,919 | $33,281 |
| Bank of New York Mellon Corp | 301,080 | $32,228 |
| First Light Asset Management, LLC | 295,844 | $31,667 |
| Invesco Ltd. | 291,150 | $31,165 |
| Candriam S.C.A. | 287,907 | $30,819 |
| Sofinnova Investments, Inc. | 271,394 | $29,050 |
| Artisan Partners Limited Partnership | 263,591 | $28,215 |
| AMERIPRISE FINANCIAL INC | 261,160 | $27,955 |
| WELLINGTON MANAGEMENT GROUP LLP | 250,156 | $26,777 |
| Voya Investment Management LLC | 249,874 | $26,747 |
| ORBIMED ADVISORS LLC | 239,800 | $25,668 |
| Hood River Capital Management LLC | 237,043 | $25,373 |
| BANK OF AMERICA CORP /DE/ | 224,484 | $24,029 |
| Logos Global Management LP | 190,000 | $20,338 |
| MILLENNIUM MANAGEMENT LLC | 186,709 | $19,985 |
| BNP PARIBAS ARBITRAGE, SA | 164,563 | $17,615 |
| CITADEL ADVISORS LLC | 153,322 | $16,412 |
| Connor, Clark & Lunn Investment Management Ltd. | 149,373 | $15,989 |
| First Turn Management, LLC | 146,303 | $15,660 |
| M&G PLC | 137,074 | $14,667 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 135,950 | $14,552 |
| Russell Investments Group, Ltd. | 134,180 | $14,363 |
| BARCLAYS PLC | 131,436 | $14,069 |
| DEUTSCHE BANK AG\ | 129,123 | $13,821 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123,537 | $13,218 |
| Nuveen, LLC | 115,934 | $12,410 |
| Capital World Investors | 115,693 | $12,384 |
| Swiss National Bank | 111,300 | $11,914 |
| NEW YORK STATE COMMON RETIREMENT FUND | 93,677 | $10,027 |
| FIRST TRUST ADVISORS LP | 88,505 | $9,474 |
| ALGERT GLOBAL LLC | 88,250 | $9 |
| AXIOM INVESTORS LLC /DE | 83,554 | $8,944 |
| Zweig-DiMenna Associates LLC | 81,600 | $8,734 |
| SummitTX Capital, L.P. | 80,729 | $8,641 |
| ExodusPoint Capital Management, LP | 75,141 | $8,043 |
| NEUBERGER BERMAN GROUP LLC | 73,572 | $7,875 |
| WELLS FARGO & COMPANY/MN | 72,617 | $7,773 |
| BALYASNY ASSET MANAGEMENT L.P. | 72,282 | $7,737 |
| RHUMBLINE ADVISERS | 71,212 | $7,623 |
| AQR CAPITAL MANAGEMENT LLC | 70,046 | $7,498 |
| NEXTBio Capital Management LP | 67,586 | $7,234 |
| NORGES BANK | 66,213 | $7,087 |
| CASTLEARK MANAGEMENT LLC | 64,479 | $6,902 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 60,575 | $6,484 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,609 | $6,372 |
| PDT Partners, LLC | 59,436 | $6,362 |
| STEMPOINT CAPITAL LP | 58,915 | $6,306 |
| EAM Investors, LLC | 57,327 | $6,136 |
| Rafferty Asset Management, LLC | 55,526 | $5,944 |
| Legal & General Group Plc | 55,075 | $5,895 |
| TD Asset Management Inc | 55,050 | $5,893 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,537 | $5,731 |
| Granahan Investment Management, LLC | 53,452 | $5,722 |
| PRUDENTIAL FINANCIAL INC | 53,145 | $5,689 |
| ADAR1 Capital Management, LLC | 51,349 | $5,496 |
| Nan Fung Group Holdings Ltd | 49,120 | $5,258 |
| VICTORY CAPITAL MANAGEMENT INC | 45,381 | $4,858 |
| WCM INVESTMENT MANAGEMENT, LLC | 44,805 | $4,783 |
| Harvest Investment Services, LLC | 43,953 | $4,705 |
| HighVista Strategies LLC | 42,867 | $4,588 |
| 176 other institutions | 1,411,416 | $138,248 |