RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

LOOMIS SAYLES & CO L P's Holding History (CIK: 0000312348)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 503,901 Value ($000) $53,938 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 527,439 Value ($000) $53,266 Avg Close $92.84 Range $62.84 - $106.52

Q2 2025

Shares 591,454 Value ($000) $37,374 Avg Close $61.23 Range $45.91 - $69.89

Q1 2025

Shares 605,764 Value ($000) $32 Avg Close $55.48 Range $47.86 - $62.14

Q4 2024

Shares 618,485 Value ($000) $35 Avg Close $55.24 Range $46.80 - $68.58

Q3 2024

Shares 636,628 Value ($000) $33 Avg Close $47.92 Range $40.46 - $55.64

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	503,901	$53,938	$106.08	$95.27 - $122.20
Q3 2025	527,439	$53,266	$92.84	$62.84 - $106.52
Q2 2025	591,454	$37,374	$61.23	$45.91 - $69.89
Q1 2025	605,764	$32	$55.48	$47.86 - $62.14
Q4 2024	618,485	$35	$55.24	$46.80 - $68.58
Q3 2024	636,628	$33	$47.92	$40.46 - $55.64