RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 59,609 Value ($000) $6,372 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 60,917 Value ($000) $6,152 Avg Close $92.84 Range $62.84 - $106.52

Q2 2025

Shares 68,132 Value ($000) $4,305 Avg Close $61.23 Range $45.91 - $69.89

Q1 2025

Shares 64,386 Value ($000) $3,411 Avg Close $55.48 Range $47.86 - $62.14

Q4 2024

Shares 59,969 Value ($000) $3,357 Avg Close $55.24 Range $46.80 - $68.58

Q3 2024

Shares 48,703 Value ($000) $2,552 Avg Close $47.92 Range $40.46 - $55.64

Q2 2024

Shares 49,291 Value ($000) $2,024 Avg Close $39.92 Range $35.17 - $45.92

Q1 2024

Shares 47,624 Value ($000) $2,064 Avg Close $43.76 Range $37.66 - $52.57

Q4 2023

Shares 39,238 Value ($000) $1,804 Avg Close $31.55 Range $20.97 - $50.27

Q3 2023

Shares 20,163 Value ($000) $462 Avg Close $22.39 Range $15.50 - $28.25

Q2 2023

Shares 20,906 Value ($000) $345 Avg Close $18.05 Range $15.52 - $21.67

Q1 2022

Shares 19,385 Value ($000) $223 Avg Close $8.78 Range $6.01 - $12.61

Q4 2021

Shares 24,695 Value ($000) $246 Avg Close $11.23 Range $8.44 - $14.21

Q3 2021

Shares 24,423 Value ($000) $319 Avg Close $15.27 Range $11.53 - $20.81

Q2 2021

Shares 25,708 Value ($000) $503 Avg Close $20.76 Range $18.19 - $23.35

Q1 2021

Shares 22,022 Value ($000) $468 Avg Close $29.00 Range $19.13 - $43.26

Q4 2020

Shares 20,294 Value ($000) $603 Avg Close $25.42 Range $20.49 - $34.27

Q3 2020

Shares 19,925 Value ($000) $432 Avg Close $22.93 Range $18.00 - $32.24

Q2 2020

Shares 20,362 Value ($000) $444 Avg Close $19.49 Range $14.12 - $25.86

Q1 2020

Shares 19,228 Value ($000) $293 Avg Close $17.90 Range $12.99 - $23.14

Q4 2019

Shares 14,451 Value ($000) $332 Avg Close $22.21 Range $19.06 - $25.84

Q3 2019

Shares 15,076 Value ($000) $319 Avg Close $21.45 Range $18.00 - $25.04

Q2 2019

Shares 15,106 Value ($000) $332 Avg Close $25.25 Range $20.64 - $29.13

Q2 2018

Shares 10,017 Value ($000) $314 Avg Close $27.34 Range $16.80 - $37.23

Q1 2018

Shares 7,268 Value ($000) $145 Avg Close $26.55 Range $19.25 - $32.35

Q4 2017

Shares 6,318 Value ($000) $184 Avg Close $26.40 Range $21.38 - $31.63

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	59,609	$6,372	$106.08	$95.27 - $122.20
Q3 2025	60,917	$6,152	$92.84	$62.84 - $106.52
Q2 2025	68,132	$4,305	$61.23	$45.91 - $69.89
Q1 2025	64,386	$3,411	$55.48	$47.86 - $62.14
Q4 2024	59,969	$3,357	$55.24	$46.80 - $68.58
Q3 2024	48,703	$2,552	$47.92	$40.46 - $55.64
Q2 2024	49,291	$2,024	$39.92	$35.17 - $45.92
Q1 2024	47,624	$2,064	$43.76	$37.66 - $52.57
Q4 2023	39,238	$1,804	$31.55	$20.97 - $50.27
Q3 2023	20,163	$462	$22.39	$15.50 - $28.25
Q2 2023	20,906	$345	$18.05	$15.52 - $21.67
Q1 2022	19,385	$223	$8.78	$6.01 - $12.61
Q4 2021	24,695	$246	$11.23	$8.44 - $14.21
Q3 2021	24,423	$319	$15.27	$11.53 - $20.81
Q2 2021	25,708	$503	$20.76	$18.19 - $23.35
Q1 2021	22,022	$468	$29.00	$19.13 - $43.26
Q4 2020	20,294	$603	$25.42	$20.49 - $34.27
Q3 2020	19,925	$432	$22.93	$18.00 - $32.24
Q2 2020	20,362	$444	$19.49	$14.12 - $25.86
Q1 2020	19,228	$293	$17.90	$12.99 - $23.14
Q4 2019	14,451	$332	$22.21	$19.06 - $25.84
Q3 2019	15,076	$319	$21.45	$18.00 - $25.04
Q2 2019	15,106	$332	$25.25	$20.64 - $29.13
Q2 2018	10,017	$314	$27.34	$16.80 - $37.23
Q1 2018	7,268	$145	$26.55	$19.25 - $32.35
Q4 2017	6,318	$184	$26.40	$21.38 - $31.63