RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

Candriam S.C.A.'s Holding History (CIK: 0001537014)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 287,907 Value ($000) $30,819 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 221,863 Value ($000) $22,406 Avg Close $92.84 Range $62.84 - $106.52

Q2 2025

Shares 312,452 Value ($000) $19,745 Avg Close $61.23 Range $45.91 - $69.89

Q1 2025

Shares 291,469 Value ($000) $15,439 Avg Close $55.48 Range $47.86 - $62.14

Q4 2024

Shares 332,392 Value ($000) $18,607 Avg Close $55.24 Range $46.80 - $68.58

Q3 2024

Shares 395,377 Value ($000) $20,713 Avg Close $47.92 Range $40.46 - $55.64

Q2 2024

Shares 271,398 Value ($000) $11,143 Avg Close $39.92 Range $35.17 - $45.92

Q4 2022

Shares 32,479 Value ($000) $946 Avg Close $25.70 Range $21.57 - $30.90

Q3 2022

Shares 38,234 Value ($000) $937 Avg Close $18.60 Range $4.08 - $30.98

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	287,907	$30,819	$106.08	$95.27 - $122.20
Q3 2025	221,863	$22,406	$92.84	$62.84 - $106.52
Q2 2025	312,452	$19,745	$61.23	$45.91 - $69.89
Q1 2025	291,469	$15,439	$55.48	$47.86 - $62.14
Q4 2024	332,392	$18,607	$55.24	$46.80 - $68.58
Q3 2024	395,377	$20,713	$47.92	$40.46 - $55.64
Q2 2024	271,398	$11,143	$39.92	$35.17 - $45.92
Q4 2022	32,479	$946	$25.70	$21.57 - $30.90
Q3 2022	38,234	$937	$18.60	$4.08 - $30.98