RHYTHM PHARMACEUTICALS INC

Ticker: RYTM CUSIP: 76243J105 Class: Common Stock

Sofinnova Investments, Inc.'s Holding History (CIK: 0001631134)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 271,394 Value ($000) $29,050 Avg Close $106.08 Range $95.27 - $122.20

Q3 2025

Shares 246,966 Value ($000) $24,941 Avg Close $92.84 Range $62.84 - $106.52

Q2 2025

Shares 586,010 Value ($000) $37,030 Avg Close $61.23 Range $45.91 - $69.89

Q1 2025

Shares 446,839 Value ($000) $23,669 Avg Close $55.48 Range $47.86 - $62.14

Q4 2024

Shares 397,428 Value ($000) $22,248 Avg Close $55.24 Range $46.80 - $68.58

Q3 2024

Shares 276,678 Value ($000) $14,495 Avg Close $47.92 Range $40.46 - $55.64

Q4 2019

Shares 21,319 Value ($000) $489 Avg Close $22.21 Range $19.06 - $25.84

Q3 2018

Shares 159,302 Value ($000) $4,646 Avg Close $31.60 Range $26.86 - $36.40

Q2 2018

Shares 14,452 Value ($000) $452 Avg Close $27.34 Range $16.80 - $37.23

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	271,394	$29,050	$106.08	$95.27 - $122.20
Q3 2025	246,966	$24,941	$92.84	$62.84 - $106.52
Q2 2025	586,010	$37,030	$61.23	$45.91 - $69.89
Q1 2025	446,839	$23,669	$55.48	$47.86 - $62.14
Q4 2024	397,428	$22,248	$55.24	$46.80 - $68.58
Q3 2024	276,678	$14,495	$47.92	$40.46 - $55.64
Q4 2019	21,319	$489	$22.21	$19.06 - $25.84
Q3 2018	159,302	$4,646	$31.60	$26.86 - $36.40
Q2 2018	14,452	$452	$27.34	$16.80 - $37.23