SAGE THERAPEUTICS INC

CUSIP: 78667J108 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 45,000 Value ($000) $3,198 Avg Close — Range —
Q4 2016
Shares 35,000 Value ($000) $1,787 Avg Close — Range —
Q1 2016
Shares 165,000 Value ($000) $5,290 Avg Close — Range —
Q4 2015
Shares 100,000 Value ($000) $5,830 Avg Close — Range —
Q3 2015
Shares 20,000 Value ($000) $846 Avg Close — Range —