| FMR LLC | 37,430,284 | $152,341 |
| Flagship Pioneering, LLC | 25,001,856 | $101,758 |
| BlackRock, Inc. | 14,223,527 | $57,890 |
| VANGUARD GROUP INC | 10,455,195 | $42,553 |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,242,100 | $41,685 |
| STATE STREET CORP | 8,054,841 | $32,783 |
| BAILLIE GIFFORD & CO | 6,609,065 | $26,899 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,118,138 | $16,763 |
| Marex Group plc | 3,732,780 | $15,192 |
| Integral Health Asset Management, LLC | 3,000,000 | $12,210 |
| Alphabet Inc. | 2,812,500 | $11,447 |
| RENAISSANCE TECHNOLOGIES LLC | 1,691,116 | $6,883 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,679,130 | $6,834 |
| TWO SIGMA INVESTMENTS, LP | 1,579,705 | $6,429 |
| GOLDMAN SACHS GROUP INC | 1,488,377 | $6,058 |
| NORTHERN TRUST CORP | 1,407,699 | $5,729 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,399,335 | $5,695 |
| Woodline Partners LP | 1,317,641 | $5,363 |
| MORGAN STANLEY | 1,285,045 | $5,230 |
| Crestline Management, LP | 1,220,937 | $4,969 |
| BANK OF AMERICA CORP /DE/ | 1,186,251 | $4,828 |
| UBS Group AG | 1,182,958 | $4,815 |
| AQR CAPITAL MANAGEMENT LLC | 1,134,324 | $4,617 |
| Omega Fund Management, LLC | 843,750 | $3,434 |
| JPMORGAN CHASE & CO | 815,455 | $3,319 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 766,487 | $3 |
| GREAT POINT PARTNERS LLC | 700,000 | $2,849 |
| ArrowMark Colorado Holdings LLC | 685,125 | $2,788 |
| JANE STREET GROUP, LLC | 668,884 | $2,722 |
| Corient Private Wealth LLC | 638,367 | $2,598 |
| MILLENNIUM MANAGEMENT LLC | 623,242 | $2,537 |
| DEUTSCHE BANK AG\ | 562,312 | $2,289 |
| Invesco Ltd. | 561,835 | $2,287 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 559,750 | $2,278 |
| BARCLAYS PLC | 509,889 | $2,075 |
| Bank of New York Mellon Corp | 457,226 | $1,861 |
| Swiss National Bank | 335,800 | $1,367 |
| Squarepoint Ops LLC | 331,741 | $1,350 |
| Nuveen, LLC | 325,212 | $1,324 |
| BAKER BROS. ADVISORS LP | 310,483 | $1,264 |
| Private Advisor Group, LLC | 309,399 | $1,259 |
| Rafferty Asset Management, LLC | 274,162 | $1,116 |
| UBS ASSET MANAGEMENT AMERICAS INC | 240,414 | $978 |
| IEQ CAPITAL, LLC | 236,692 | $963 |
| TWO SIGMA ADVISERS, LP | 221,671 | $902 |
| WELLS FARGO & COMPANY/MN | 191,081 | $778 |
| RHUMBLINE ADVISERS | 189,412 | $771 |
| ALLIANCEBERNSTEIN L.P. | 186,945 | $761 |
| Susquehanna Portfolio Strategies, LLC | 167,503 | $682 |
| Clarius Group, LLC | 166,065 | $676 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 164,791 | $671 |
| Voya Investment Management LLC | 163,536 | $666 |
| CITIGROUP INC | 154,764 | $630 |
| Legal & General Group Plc | 151,018 | $615 |
| DIMENSIONAL FUND ADVISORS LP | 133,078 | $542 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 130,291 | $530 |
| STATE OF WISCONSIN INVESTMENT BOARD | 128,856 | $524 |
| Palumbo Wealth Management LLC | 120,983 | $492 |
| Virtu Financial LLC | 119,312 | $0 |
| XTX Topco Ltd | 117,376 | $478 |
| DekaBank Deutsche Girozentrale | 112,300 | $1 |
| PROFUND ADVISORS LLC | 102,046 | $415 |
| SG Americas Securities, LLC | 98,287 | $0 |
| GILDER GAGNON HOWE & CO LLC | 94,072 | $383 |
| HSBC HOLDINGS PLC | 94,064 | $375 |
| MetLife Investment Management, LLC | 93,126 | $379 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 91,975 | $375 |
| MARSHALL WACE, LLP | 88,788 | $361 |
| CWM, LLC | 85,106 | $0 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 82,393 | $335 |
| SCS Capital Management LLC | 81,250 | $331 |
| TD Asset Management Inc | 80,600 | $328 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 77,350 | $315 |
| Brevan Howard Capital Management LP | 70,607 | $287 |
| FRANKLIN RESOURCES INC | 69,401 | $282 |
| VARCOV Co. | 64,907 | $264 |
| NewEdge Advisors, LLC | 64,399 | $262 |
| D. E. Shaw & Co., Inc. | 60,900 | $248 |
| Creative Planning | 60,899 | $248 |
| Quinn Opportunity Partners LLC | 60,100 | $245 |
| ALGERT GLOBAL LLC | 60,010 | $0 |
| SRS Capital Advisors, Inc. | 59,028 | $240 |
| JANUS HENDERSON GROUP PLC | 58,189 | $237 |
| BIT Capital GmbH | 58,000 | $236 |
| Schonfeld Strategic Advisors LLC | 55,842 | $227 |
| AXQ CAPITAL, LP | 55,403 | $225 |
| Modus Advisors, LLC | 55,000 | $224 |
| INTECH INVESTMENT MANAGEMENT LLC | 53,295 | $217 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 53,071 | $231 |
| Virtus Investment Advisers, LLC | 51,756 | $211 |
| Arizona State Retirement System | 47,342 | $193 |
| Police & Firemen's Retirement System of New Jersey | 44,245 | $180 |
| China Universal Asset Management Co., Ltd. | 43,404 | $177 |
| Cerity Partners LLC | 42,417 | $173 |
| Focus Partners Wealth | 42,156 | $172 |
| ProShare Advisors LLC | 42,126 | $171 |
| Pallas Capital Advisors LLC | 39,627 | $161 |
| RAYMOND JAMES FINANCIAL INC | 39,273 | $160 |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,609 | $157 |
| EVOKE WEALTH, LLC | 38,569 | $157 |
| 102 other institutions | 1,096,276 | $4,065 |