| NEA Management Company, LLC | 24,471,264 | $147,562 |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | $106,132 |
| VR Adviser, LLC | 13,740,375 | $82,854 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,000 | $81,821 |
| TCG Crossover Management, LLC | 12,362,205 | $74,544 |
| BlackRock, Inc. | 11,097,289 | $66,917 |
| VANGUARD GROUP INC | 10,041,647 | $60,551 |
| Frazier Life Sciences Management, L.P. | 9,862,301 | $59,470 |
| Polar Capital Holdings Plc | 8,306,196 | $50,086 |
| Nantahala Capital Management, LLC | 7,344,783 | $44,289 |
| RTW INVESTMENTS, LP | 5,952,380 | $35,893 |
| MARSHALL WACE, LLP | 4,559,921 | $27,496 |
| STATE STREET CORP | 4,333,022 | $26,128 |
| Woodline Partners LP | 4,244,640 | $25,595 |
| EMERALD ADVISERS, LLC | 3,495,496 | $21,078 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,417,769 | $20,613 |
| Rosalind Advisors, Inc. | 3,403,721 | $20,524 |
| Affinity Asset Advisors, LLC | 2,797,153 | $16,867 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,674,931 | $16,130 |
| Spruce Street Capital LP | 2,411,093 | $14,539 |
| PERCEPTIVE ADVISORS LLC | 2,400,000 | $14,472 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,396,458 | $14,451 |
| MORGAN STANLEY | 2,337,896 | $14,098 |
| NAN FUNG TRINITY (HK) LTD | 1,688,500 | $10,182 |
| D. E. Shaw & Co., Inc. | 1,669,370 | $10,066 |
| Vestal Point Capital, LP | 1,606,000 | $9,684 |
| ADAR1 Capital Management, LLC | 1,405,452 | $8,475 |
| Longaeva Partners L.P. | 1,246,042 | $7,514 |
| SPHERA FUNDS MANAGEMENT LTD. | 1,178,164 | $7,104 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,161,672 | $7,005 |
| NORTHERN TRUST CORP | 1,077,625 | $6,498 |
| BNP Paribas Investment Partners S.A. | 1,061,198 | $6 |
| Siren, L.L.C. | 1,000,000 | $6,030 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 995,353 | $6,002 |
| Swedbank AB | 850,000 | $5,126 |
| DEUTSCHE BANK AG\ | 824,717 | $4,973 |
| CITADEL ADVISORS LLC | 774,492 | $4,670 |
| Voya Investment Management LLC | 751,255 | $4,530 |
| Invesco Ltd. | 688,595 | $4,152 |
| F/M Investments LLC | 678,813 | $4,093 |
| Sio Capital Management, LLC | 613,888 | $3,702 |
| KVP Capital Advisors, LP | 605,280 | $3,650 |
| JANE STREET GROUP, LLC | 584,289 | $3,523 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 543,756 | $3,279 |
| MILLENNIUM MANAGEMENT LLC | 534,968 | $3,226 |
| GOLDMAN SACHS GROUP INC | 516,598 | $3,115 |
| BANK OF AMERICA CORP /DE/ | 423,596 | $2,554 |
| SummitTX Capital, L.P. | 373,034 | $2,249 |
| RENAISSANCE TECHNOLOGIES LLC | 332,100 | $2,003 |
| Bank of New York Mellon Corp | 312,870 | $1,887 |
| BARCLAYS PLC | 306,940 | $1,851 |
| Sofinnova Investments, Inc. | 304,770 | $1,838 |
| Nuveen, LLC | 272,602 | $1,644 |
| UBS Group AG | 202,883 | $1,223 |
| BALYASNY ASSET MANAGEMENT L.P. | 188,214 | $1,135 |
| Eversept Partners, LP | 170,195 | $1,026 |
| DIMENSIONAL FUND ADVISORS LP | 170,129 | $1,026 |
| WELLS FARGO & COMPANY/MN | 167,644 | $1,011 |
| RHUMBLINE ADVISERS | 152,775 | $921 |
| Walleye Capital LLC | 150,084 | $905 |
| GSA CAPITAL PARTNERS LLP | 140,753 | $1 |
| ALLIANCEBERNSTEIN L.P. | 127,040 | $766 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90,000 | $550 |
| Rafferty Asset Management, LLC | 89,858 | $542 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 86,160 | $520 |
| Cresset Asset Management, LLC | 83,334 | $503 |
| Aquatic Capital Management LLC | 83,089 | $501 |
| MetLife Investment Management, LLC | 78,551 | $474 |
| Connor, Clark & Lunn Investment Management Ltd. | 74,882 | $452 |
| OXFORD ASSET MANAGEMENT LLP | 74,115 | $447 |
| JPMORGAN CHASE & CO | 73,059 | $441 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,014 | $429 |
| Jump Financial, LLC | 70,695 | $426 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69,536 | $0 |
| Virtu Financial LLC | 65,615 | $0 |
| Seven Fleet Capital Management LP | 62,762 | $378 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 60,637 | $366 |
| Susquehanna Portfolio Strategies, LLC | 59,469 | $359 |
| Graham Capital Management, L.P. | 56,013 | $338 |
| Creative Planning | 55,719 | $336 |
| BANK OF NOVA SCOTIA | 51,700 | $312 |
| Sivia Capital Partners, LLC | 48,507 | $292 |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 46,000 | $277 |
| SG Americas Securities, LLC | 45,526 | $0 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,547 | $263 |
| Brevan Howard Capital Management LP | 41,652 | $251 |
| INTECH INVESTMENT MANAGEMENT LLC | 40,958 | $247 |
| EntryPoint Capital, LLC | 40,716 | $246 |
| Caitong International Asset Management Co., Ltd | 39,649 | $239 |
| Virtus Investment Advisers, LLC | 38,443 | $232 |
| Jain Global LLC | 37,705 | $227 |
| Brooklyn Investment Group | 36,809 | $233 |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,555 | $220 |
| PROFUND ADVISORS LLC | 35,145 | $212 |
| ProShare Advisors LLC | 34,869 | $210 |
| Police & Firemen's Retirement System of New Jersey | 33,925 | $205 |
| China Universal Asset Management Co., Ltd. | 33,155 | $200 |
| OSAIC HOLDINGS, INC. | 32,678 | $197 |
| BNP PARIBAS ARBITRAGE, SA | 31,204 | $188 |
| FMR LLC | 27,849 | $168 |
| 47 other institutions | 393,868 | $2,256 |