SEMLER SCIENTIFIC INC

Ticker: SMLR CUSIP: 81684M104 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 70,000 Value ($000) $3,469 Avg Close $67.02 Range $41.53 - $93.98

Q4 2021

Shares 172,000 Value ($000) $15,764 Avg Close $112.08 Range $88.32 - $153.21

Q3 2021

Shares 225,566 Value ($000) $28,203 Avg Close $114.32 Range $101.50 - $133.54

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	70,000	$3,469	$67.02	$41.53 - $93.98
Q4 2021	172,000	$15,764	$112.08	$88.32 - $153.21
Q3 2021	225,566	$28,203	$114.32	$101.50 - $133.54