SEPTERNA INC

Ticker: SEPN CUSIP: 81734D104 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,995,858 Value ($000) $195,045 Avg Close $23.88 Range $17.55 - $30.50

Q3 2025

Shares 6,995,858 Value ($000) $131,592 Avg Close $13.12 Range $10.30 - $18.99

Q2 2025

Shares 6,995,858 Value ($000) $73,946 Avg Close $8.24 Range $4.66 - $11.36

Q1 2025

Shares 6,995,858 Value ($000) $40,506 Avg Close $11.42 Range $4.17 - $23.85

Q4 2024

Shares 6,995,858 Value ($000) $160,205 Avg Close $23.65 Range $18.62 - $28.99

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,995,858	$195,045	$23.88	$17.55 - $30.50
Q3 2025	6,995,858	$131,592	$13.12	$10.30 - $18.99
Q2 2025	6,995,858	$73,946	$8.24	$4.66 - $11.36
Q1 2025	6,995,858	$40,506	$11.42	$4.17 - $23.85
Q4 2024	6,995,858	$160,205	$23.65	$18.62 - $28.99