| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | $195,045 |
| TRV GP V, LLC | 6,215,591 | $173,291 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,809,470 | $134,088 |
| TRV GP VI, LLC | 4,211,659 | $117,421 |
| Samsara BioCapital, LLC | 3,149,128 | $87,798 |
| GOLDMAN SACHS GROUP INC | 2,715,129 | $75,698 |
| Siren, L.L.C. | 2,000,000 | $55,760 |
| BlackRock, Inc. | 1,801,328 | $50,221 |
| BVF INC/IL | 1,720,782 | $47,975 |
| VANGUARD GROUP INC | 1,508,195 | $42,048 |
| Avoro Capital Advisors LLC | 1,337,500 | $37,290 |
| ADAR1 Capital Management, LLC | 1,157,611 | $32,274 |
| First Light Asset Management, LLC | 620,811 | $17,308 |
| VR Adviser, LLC | 610,808 | $17,029 |
| GEODE CAPITAL MANAGEMENT, LLC | 572,734 | $15,971 |
| Casdin Capital, LLC | 553,268 | $15,425 |
| PRIMECAP MANAGEMENT CO/CA/ | 546,100 | $15,225 |
| STATE STREET CORP | 540,028 | $15,056 |
| PERCEPTIVE ADVISORS LLC | 433,160 | $12,077 |
| Woodline Partners LP | 385,310 | $10,742 |
| Soleus Capital Management, L.P. | 383,368 | $10,688 |
| Catalio Capital Management, LP | 294,360 | $8,207 |
| MARSHALL WACE, LLP | 226,901 | $6,326 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $6,209 |
| Kalehua Capital Management LLC | 194,544 | $5,424 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 187,241 | $5,220 |
| Invesco Ltd. | 162,014 | $4,517 |
| NORTHERN TRUST CORP | 154,196 | $4,299 |
| MILLENNIUM MANAGEMENT LLC | 107,463 | $2,996 |
| MORGAN STANLEY | 103,985 | $2,899 |
| TWO SIGMA INVESTMENTS, LP | 92,809 | $2,588 |
| FEDERATED HERMES, INC. | 78,905 | $2,200 |
| HighVista Strategies LLC | 78,682 | $2,194 |
| CITADEL ADVISORS LLC | 75,945 | $2,117 |
| UBS Group AG | 68,817 | $1,919 |
| JPMORGAN CHASE & CO | 68,338 | $1,905 |
| Rangeley Capital, LLC | 65,800 | $1,835 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 61,370 | $1,711 |
| Bank of New York Mellon Corp | 55,332 | $1,543 |
| AMERICAN CENTURY COMPANIES INC | 50,689 | $1,413 |
| Longaeva Partners L.P. | 49,902 | $1,391 |
| Numerai GP LLC | 45,866 | $1,279 |
| JANE STREET GROUP, LLC | 44,070 | $1,229 |
| Trexquant Investment LP | 44,005 | $1,227 |
| BARCLAYS PLC | 38,147 | $1,064 |
| ExodusPoint Capital Management, LP | 37,867 | $1,056 |
| BANK OF AMERICA CORP /DE/ | 37,594 | $1,048 |
| Alyeska Investment Group, L.P. | 35,000 | $976 |
| ALGERT GLOBAL LLC | 34,944 | $1 |
| ACADIAN ASSET MANAGEMENT LLC | 30,877 | $1 |
| WELLS FARGO & COMPANY/MN | 26,529 | $740 |
| RHUMBLINE ADVISERS | 26,419 | $737 |
| Nuveen, LLC | 25,798 | $719 |
| TWO SIGMA ADVISERS, LP | 25,700 | $717 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,443 | $1 |
| Logos Global Management LP | 23,548 | $657 |
| XTX Topco Ltd | 23,315 | $650 |
| VARCOV Co. | 22,634 | $631 |
| ALLIANCEBERNSTEIN L.P. | 19,600 | $546 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18,550 | $399 |
| TUDOR INVESTMENT CORP ET AL | 18,053 | $503 |
| FRANKLIN RESOURCES INC | 16,852 | $470 |
| Russell Investments Group, Ltd. | 15,310 | $427 |
| DEUTSCHE BANK AG\ | 14,879 | $415 |
| Squarepoint Ops LLC | 14,847 | $414 |
| STRS OHIO | 14,600 | $407 |
| AMERIPRISE FINANCIAL INC | 14,090 | $393 |
| MetLife Investment Management, LLC | 13,685 | $382 |
| INTECH INVESTMENT MANAGEMENT LLC | 13,283 | $370 |
| OSAIC HOLDINGS, INC. | 12,693 | $354 |
| Seven Fleet Capital Management LP | 11,445 | $319 |
| Dynamic Technology Lab Private Ltd | 10,810 | $301 |
| PharVision Advisers, LLC | 10,739 | $299 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 10,594 | $295 |
| Virtus Investment Advisers, LLC | 10,457 | $292 |
| China Universal Asset Management Co., Ltd. | 10,296 | $287 |
| Baader Bank Aktiengesellschaft | 10,000 | $279 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,934 | $277 |
| Atom Investors LP | 9,791 | $273 |
| CITIGROUP INC | 9,561 | $267 |
| Graham Capital Management, L.P. | 8,971 | $250 |
| Jump Financial, LLC | 8,399 | $234 |
| BANK OF NOVA SCOTIA | 8,300 | $231 |
| AQR CAPITAL MANAGEMENT LLC | 7,826 | $218 |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,600 | $156 |
| BNP PARIBAS ARBITRAGE, SA | 5,449 | $152 |
| Police & Firemen's Retirement System of New Jersey | 5,175 | $144 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,571 | $100 |
| FMR LLC | 3,307 | $92 |
| Caitong International Asset Management Co., Ltd | 3,170 | $88 |
| Mirae Asset Global Investments Co., Ltd. | 2,176 | $61 |
| Tower Research Capital LLC (TRC) | 2,156 | $60 |
| Legal & General Group Plc | 1,945 | $54 |
| Ameritas Investment Partners, Inc. | 1,944 | $54 |
| Covestor Ltd | 1,941 | $0 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,316 | $37 |
| Global Retirement Partners, LLC | 1,256 | $35 |
| Sterling Capital Management LLC | 1,232 | $34 |
| SIGNATUREFD, LLC | 989 | $28 |
| GROUP ONE TRADING, L.P. | 944 | $26 |
| 22 other institutions | 6,705 | $140 |