SEPTERNA INC

Ticker: SEPN CUSIP: 81734D104 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 25,700 Value ($000) $717 Avg Close $23.88 Range $17.55 - $30.50

Q3 2025

Shares 20,700 Value ($000) $389 Avg Close $13.12 Range $10.30 - $18.99

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	25,700	$717	$23.88	$17.55 - $30.50
Q3 2025	20,700	$389	$13.12	$10.30 - $18.99